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The PI resigned the institute, and the rest investigators at the institute decided to terminate the study.
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The investigators would like to propose a prospective longitudinal observational cohort study for patients who will be diagnosed and/or treated for acute lymphoblastic leukemia at Asan Medical Center, Seoul, Korea, to use the acquired data for fundamentals of other retrospective analysis.
Acquisition of informed concent form
Data acquisition from medical record including
Accumulation of data for 30 years
Use of data for other retrospective analysis (including Asan Medical center Cell Banking basic data)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ph-ALL | Diagnosed as ALL with Philadelphia-negative |
| |
| Ph+ALL | Diagnosed as ALL with Philadelphia-positive (including biphenotypic acute leukemia with Philadelphia-positive) |
| |
| Other ALL | Diagnosed as ALL of other type, including Burkitt leukemia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diagnosed as ALL | Other | All patients who will be enrolled in this prospective registry are confined to those who are diagnosed as acute lymphoblastic leukemia at Asan Medical Center, Seoul, Korea, from Jan 2013 till Dec 2047 |
| Measure | Description | Time Frame |
|---|---|---|
| Overall survival | 10 year |
| Measure | Description | Time Frame |
|---|---|---|
| Event-free survival | Definition of events will be as 'relapse', 'death from any cause'. Relapse will be defined as hematologic relapse and molecular relapse, respectively when the patient is diagnosed as Philadelphia-positive acute lymphoblastic leukemia | 10 years |
| Relapse-free survival |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who are diagnosed and/or treated with acute lymphoblastic leukemia at Asan Medical Center, Seoul, Korea
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| Name | Affiliation | Role |
|---|---|---|
| Dae-Young Kim, MD, PhD | Associate Professor | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Asan Medical Center | Seoul | 138-736 | South Korea |
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| ID | Term |
|---|---|
| D054198 | Precursor Cell Lymphoblastic Leukemia-Lymphoma |
| D015452 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma |
| D015456 | Leukemia, Biphenotypic, Acute |
| ID | Term |
|---|---|
| D007945 | Leukemia, Lymphoid |
| D007938 | Leukemia |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
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Bone marrow aspirate or peripheral blood (for its mononuclear cells) will be collected, processed, and cryopreserved for future analysis of DNA or cell culture. Acquisition of biospecimens will be proceeded if patient agree with the informed consent for donation of biospecimen to 'Asan Medical Center Biomaterial Resource Banking Center'. This registry data will be used as a basic demographic and clinical information for the biospecimens.
|
Relapse will be defined as hematologic relapse and molecular relapse, respectively when the patient is diagnosed as Philadelphia-positive acute lymphoblastic leukemia |
| 10 years |
| D006402 |
| Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |