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The PI resigned the institute. The rest investigators at the institute decided to terminate the study.
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The investigators would like to propose a prospective longitudinal observational cohort study for patients who will be diagnosed and/or treated for chronic myeloid leukemia at Asan Medical Center, Seoul, Korea, to use the acquired data for fundamentals of other retrospective analysis.
Acquisition of informed concent form
Data acquisition from medical record including
Accumulation of data for 30 years
Use of data for other retrospective analysis (including Asan Medical center Cell Banking basic data)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CML CP | Diagnosed as CML with chronic phase |
| |
| CML AP | Diagnosed as CML with accelerated phase |
| |
| CML BC | Diagnosed as CML with blast crisis |
| |
| CML other | Diagnosed as CML, which is not included in any of other category |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diagnosed as CML | Other | All patients who will be enrolled in this prospective registry are confined to those who are diagnosed as chronic myeloid leukemia at Asan Medical Center, Seoul, Korea, from Jan 2013 till Dec 2047 |
| Measure | Description | Time Frame |
|---|---|---|
| Overall survival | 30 years |
| Measure | Description | Time Frame |
|---|---|---|
| Event-free survival | Definition of events will be as 'failure', 'progress to AP/BC', 'intolerant and medication change', and 'death from any cause'. | 30 years |
| Failure-free survival | Failure will be defined as BCR-ABL elevation at 2 serial times, progression to AP/BC, loss of hematologic / cytogenetic response, any appearance of ABL kinase mutation, and clonal evolution. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who are diagnosed and/or treated with chronic myeloid leukemia at Asan Medical Center, Seoul, Korea
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| Name | Affiliation | Role |
|---|---|---|
| Dae-Young Kim, MD | Assistant Professor | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Asan Medical Center | Seoul | 138-736 | South Korea |
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| ID | Term |
|---|---|
| D015464 | Leukemia, Myelogenous, Chronic, BCR-ABL Positive |
| D015465 | Leukemia, Myeloid, Accelerated Phase |
| D015466 | Leukemia, Myeloid, Chronic-Phase |
| ID | Term |
|---|---|
| D007951 | Leukemia, Myeloid |
| D007938 | Leukemia |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
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Bone marrow aspirate or peripheral blood (for its mononuclear cells) will be collected, processed, and cryopreserved for future analysis of DNA or cell culture. Acquisition of biospecimens will be proceeded if patient agree with the informed consent for donation of biospecimen to 'Asan Medical Center Biomaterial Resource Banking Center'. This registry data will be used as a basic demographic and clinical information for the biospecimens.
|
| 30 years |
| D009196 |
| Myeloproliferative Disorders |
| D001855 | Bone Marrow Diseases |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |