Classification Of Acute Lymphoblastic Leukemia
Classification Of Acute Lymphoblastic Leukemia
This clinical trial is studying risk-group classification of patients with newly diagnosed acute lymphoblastic leukemia. Developing a risk-group classification guide may help doctors assign patients with newly diagnosed acute lymphoblastic leukemia to treatment clinical trials.
OBJECTIVES:
I. Provide a classification guide that will organize the clinical and laboratory data necessary for assigning each patient with newly diagnosed acute lymphoblastic leukemia (ALL) to a specific treatment clinical trial.
II. Provide an administrative base to capture classification data for correlative studies accompanying current Children's Oncology Group (COG) ALL treatment clinical trials.
III. Provide a central reference guide for all required and research only ALL studies that will be conducted at local and reference laboratories.
IV. Provide a mechanism for optional banking of leukemia and germline specimens for current and future research.
OUTLINE:
Patients undergo blood collection and bone marrow biopsies at baseline and at the end of induction therapy for immunophenotyping for marker identification; molecular testing for translocations; trisomy analysis by fluorescence in situ hybridization (FISH); and DNA ploidy. Immunophenotype results obtained on this study are used to determine the patient's assignment to specific treatment clinical trials (consistent with acute lymphoblastic leukemia).
After completion of induction therapy, patients are followed once or twice annually.
Inclusion Criteria:
Newly diagnosed acute lymphoblastic leukemia, defined by any of the following:
No prior registration on this study
San Francisco, California 94143, United States
Denver, Colorado 80218, United States
Washington D.C., District of Columbia 20057, United States
Hollywood, Florida 33021, United States
Miami, Florida 33136, United States
Minneapolis, Minnesota 55404, United States
New Hyde Park, New York 11040, United States
San Antonio, Texas 78229-3900, United States
Spokane, Washington 99204, United States