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No signal on pain-score
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To evaluate the effects of bilateral dual transversus abdominis plane block on postoperative pain after robotic assited laparoskopic surgery and measure the plasma-level of ropivacain after the bilateral dual transversus abdominis plane block.
After randomisation patients for robotic assisted laparoscopic surgery will receive bilateral dual transversus abdominis plane block containing either ropivacain or isotonic potassium chloride.
The investigators will record pain-score, opioid-consumption and sensibility on the abdominal wall in the postoperative periode.
Also a blood sample will be taken at 15, 30, 60, 120 and 240 minutes after the block in order to measure the plasma-level of ropivacain after bilateral dual transversus abdominis plane block.
The investigators assume that there will be significant effect on postoperative pain and that the level of plasma-ropivacain will be acceptable.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ropivacain | Active Comparator | Ropicacain 3,75 mg/ml 15 ml x 4 when placing the Bilateral Dual Transverus Abdominis Plane block |
|
| Isotonic potassium chloride | Placebo Comparator | Isotonic potassium chloride 15 ml x 4 when placing the bilateral dual transverus abdominis plane block. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ropivacaine | Drug | Ropicacain 3,75 mg/ml 15 ml x 4 when placing the Bilateral Dual Transverus Abdominis Plane block |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pain-score on numerical rating scale | 4 hours after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Administration of opioids | The first 24 hours after surgery. | |
| Pain-score on numerical rating scale | 8 hours after surgery | |
| Pain-score on numerical rating scale |
| Measure | Description | Time Frame |
|---|---|---|
| Thermoanalgesia at dermatome-level th6-th12 | 1 hour after bilateral dual transversus abdominis plane block | |
| Plasma-ropivacain level | 15, 30, 60, 120 and 240 mins after the block |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aalborg Hospital | Aalborg | Region Nord | 9000 | Denmark |
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| Isotonic potassium chloride | Drug | Isotonic potassium chloride 15 ml x 4 when placing the bilateral dual transverus abdominis plane block. |
|
| 24 hours after surgery |
| ID | Term |
|---|---|
| D000377 | Agnosia |
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D000077212 | Ropivacaine |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |
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