Antipsychotic Discontinuation in High-risk Subjects

Antipsychotic Discontinuation in High-risk Subjects

• Would be there any difference in dopamine synthesis between remitted clinical high risk subjects for psychosis and healthy control?
• What would happen to dopamine synthesis after antipsychotic discontinuation in clinical high risk subjects for psychosis?
• What about the dopamine synthesis in recurred clinical high risk subjects for psychosis after the discontinuation?

After the antipsychotic medication discontinuation, we are going to assess the changes of the biological markers

Inclusion Criteria:

• Diagnosed as a clinical High Risk
• Treated with antipsychotic drugs
• PSP1-5 (from SIPS criteria) <3 (severity index)for more than 6 months
• Had not experienced a symptomatic relapse in the 6 months

Exclusion Criteria:

• Significant abnormality in laboratory tests
• History of head trauma