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The purpose of this study is to evaluate abnormal dopamine synthesis and connectivity according to the antipsychotic treatment response in schizophrenia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Clozapine | stable patients treated with clozapine |
| |
| Other antipsychotics | stable patients treated with risperidone or paliperidone or olanzapine |
| |
| Healthy volunteer | healthy controls |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| patients treated with antipsychotics | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Striatal [18F]-DOPA uptake measured using positron emission tomographic 18F-dopa imaging. | within 2 weeks from enrollment |
| Measure | Description | Time Frame |
|---|---|---|
| resting state functional magnetic resonance imaging | within 2 weeks from enrollment | |
| diffusion tensor imaging | within 2 weeks from enrollment | |
| clinical measure including Positive and Negative Syndrome Scale |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | South Korea |
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D014150 | Antipsychotic Agents |
| ID | Term |
|---|---|
| D014149 | Tranquilizing Agents |
| D002492 | Central Nervous System Depressants |
| D045505 | Physiological Effects of Drugs |
| D020228 | Pharmacologic Actions |
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| within 2 weeks from enrollment |
| neurocognitive function test | within 2 weeks from enrollment |
| D020164 | Chemical Actions and Uses |
| D002491 | Central Nervous System Agents |
| D045506 | Therapeutic Uses |
| D011619 | Psychotropic Drugs |