This open-label, non-randomized, prospective study will evaluate the risk of symptoms recurrence during the ten years after antipsychotic discontinuation in a sample of functionally recovered first-episode patients with schizophrenia spectrum disorder.

Inclusion Criteria:

• Individuals included in the First Episode Psychosis Clinical Program (PAFIP) at the University Hospital Marqués de Valdecilla (Santander, Spain).
• A minimum of 18 months on antipsychotic treatment.
• Meeting clinical remission criteria for at least the 12 months prior to inclusion.
• Meeting the functional recovery criteria for at least the 6 months prior to inclusion.
• Stabilized at the lowest effective doses for at least the 3 months prior to inclusion.

Exclusion Criteria:

• Meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria for drug dependence.
• Meeting DSM-IV criteria for mental retardation.
• Having a history of neurological disease or head injury.