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| Name | Class |
|---|---|
| German Federal Ministry of Education and Research | OTHER_GOV |
| German Research Network On Schizophrenia | NETWORK |
| Janssen-Cilag Ltd. | INDUSTRY |
| University of Bonn |
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After one year neuroleptic maintenance treatment in patients with first episode schizophrenia, neuroleptic treatment will be continued vs. stepwise discontinued (randomized design) over a period of 1 year. Under both conditions prodrome based early intervention take place.
After one year neuroleptic maintenance treatment in patients with first episode schizophrenia, neuroleptic treatment will be continued vs. stepwise discontinued (randomized design) over a period of 1 year. Under both conditions pharmacologic early intervention strategies in case of early sign of relapse will be applied.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator | further maintenance antipsychotic treatment and prodrome-based early intervention |
|
| 2 | Experimental | stepwise drug discontinuation (after 1 year maintenance antipsychotic treatment) and prodrome-based early intervention |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| maintained antipsychotic treatment vs. stepwise drug discontinuation | Other | maintained antipsychotic treatment (in low dose) vs. stepwise drug discontinuation; both supplemented by prodrome-based early intervention; 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| relapse rate | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| psychopathology | 1 year | |
| social and cognitive functioning | 1 year | |
| side-effects |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Wolfgang Gaebel, Professor | Department of Psychiatry and Psychotherapy at the Heinrich-Heine-University of Düsseldorf, Rhineland State Clinics Düsseldorf, Bergische Landstraße 2, 40629 Düsseldorf, Germany | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| German Research Network on Schizophrenia, Department of Psychiatry and Psychotherapy at the Heinrich-Heine-University Düsseldorf | Düsseldorf | North Rhine-Westphalia | 40629 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15146342 | Background | Gaebel W, Moller HJ, Buchkremer G, Ohmann C, Riesbeck M, Wolwer W, Von Wilmsdorff M, Bottlender R, Klingberg S. Pharmacological long-term treatment strategies in first episode schizophrenia--study design and preliminary results of an ongoing RCT within the German Research Network on Schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2004 Apr;254(2):129-40. doi: 10.1007/s00406-004-0509-y. | |
| 22926606 |
| Label | URL |
|---|---|
| Click here for more information about this study: Pharmacological long-term treatment strategies for relapse prevention in first episode schizophrenia | View source |
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| D011618 | Psychotic Disorders |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
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| OTHER |
| Humboldt-Universität zu Berlin | OTHER |
| Ludwig-Maximilians - University of Munich | OTHER |
| University of Göttingen | OTHER |
| University of Cologne | OTHER |
| Mainz University | OTHER |
| University Hospital Tuebingen | OTHER |
| Universität Duisburg-Essen | OTHER |
| University of Mannheim | OTHER |
| University of Jena | OTHER |
| Martin-Luther-Universität Halle-Wittenberg | OTHER |
| RWTH Aachen University | OTHER |
| University of Wuerzburg | OTHER |
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| 1 year |
| drop-out | 1 year |
| quality of life | 1 year |
| Derived |
| Seemuller F, Schennach R, Mayr A, Musil R, Jager M, Maier W, Klingenberg S, Heuser I, Klosterkotter J, Gastpar M, Schmitt A, Schlosser R, Schneider F, Ohmann C, Lewitzka U, Gaebel W, Moller HJ, Riedel M; German Study Group on First-Episode Schizophrenia. Akathisia and suicidal ideation in first-episode schizophrenia. J Clin Psychopharmacol. 2012 Oct;32(5):694-8. doi: 10.1097/JCP.0b013e3182677958. |
| 20673559 | Derived | Gaebel W, Riesbeck M, Wolwer W, Klimke A, Eickhoff M, von Wilmsdorff M, Lemke M, Heuser I, Maier W, Huff W, Schmitt A, Sauer H, Riedel M, Klingberg S, Kopcke W, Ohmann C, Moller HJ; German Study Group on First-Episode Schizophrenia. Relapse prevention in first-episode schizophrenia--maintenance vs intermittent drug treatment with prodrome-based early intervention: results of a randomized controlled trial within the German Research Network on Schizophrenia. J Clin Psychiatry. 2011 Feb;72(2):205-18. doi: 10.4088/JCP.09m05459yel. Epub 2010 Jun 29. |