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| Name | Class |
|---|---|
| German Federal Ministry of Education and Research | OTHER_GOV |
| German Research Network On Schizophrenia | NETWORK |
| Janssen-Cilag Ltd. | INDUSTRY |
| University of Bonn |
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Prodrome based early intervention with an antipsychotic drug vs. benzodiazepine was applied in patients with first episode schizophrenia after one year neuroleptic maintenance treatment. Two groups of patients were followed over a period of 1 year: one further on under maintenance neuroleptic treatment, the other one after stepwise drug discontinuation.
In case of early signs of a relapse prodrome based early intervention with an antipsychotic drug (Haloperidol, Risperidone and other) vs. benzodiazepine (Lorazepam) was applied in patients with first episode schizophrenia after one year neuroleptic maintenance treatment. Two groups of patients were followed over a period of 1 year: one further on under maintenance neuroleptic treatment (Haloperidol, Risperidone and other) , the other one after stepwise drug discontinuation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | Early intervention with benzodiazepines in case of prodromal symptoms of an impending relapse |
|
| 2 | Active Comparator | Early intervention with antipsychotics in case of prodromal symptoms of an impending relapse |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| antipsychotics vs. Lorazepam (Drugs) | Drug | Early intervention with low-dose antipsychotics vs. lorazepam (up to 3 mg/day) in case of early warning signs of an impending relapse; |
|
| Measure | Description | Time Frame |
|---|---|---|
| relapse rate | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| psychopathology | 1 year | |
| social and cognitive functioning | 1 year | |
| side-effects |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Wolfgang Gaebel, Professor | Department of Psychiatry and Psychotherapy, University of Düsseldorf, Rhineland State Clinics Düsseldorf, Bergische Landstraße 2, 40629 Düsseldorf | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| German Research Network on Schizophrenia, Department of Psychiatry and Psychotherapy at the Heinrich-Heine-University Düsseldorf | Düsseldorf | North Rhine-Westphalia | 40629 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15146342 | Background | Gaebel W, Moller HJ, Buchkremer G, Ohmann C, Riesbeck M, Wolwer W, Von Wilmsdorff M, Bottlender R, Klingberg S. Pharmacological long-term treatment strategies in first episode schizophrenia--study design and preliminary results of an ongoing RCT within the German Research Network on Schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2004 Apr;254(2):129-40. doi: 10.1007/s00406-004-0509-y. |
| Label | URL |
|---|---|
| Click here for more information about this study: Pharmacological long-term treatment strategies for relapse prevention in first episode schizophrenia | View source |
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| D011618 | Psychotic Disorders |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D004364 | Pharmaceutical Preparations |
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| OTHER |
| Humboldt-Universität zu Berlin | OTHER |
| Ludwig-Maximilians - University of Munich | OTHER |
| University of Göttingen | OTHER |
| University of Cologne | OTHER |
| Mainz University | OTHER |
| University Hospital Tuebingen | OTHER |
| Universität Duisburg-Essen | OTHER |
| University of Mannheim | OTHER |
| University of Jena | OTHER |
| Martin-Luther-Universität Halle-Wittenberg | OTHER |
| RWTH Aachen University | OTHER |
| University of Wuerzburg | OTHER |
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| 1 year |
| drop-out | 1 year |
| quality of life | 1 year |