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| Name | Class |
|---|---|
| University of Milan | OTHER |
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The aim of the present investigation was to evaluate the effect of stevioside and rebaudioside on several variables related to caries development. Two approaches were performed: an in vitro evaluation of the growth of a culture of mutans streptococci and in vivo randomized study on the effect of a single rinse containing stevioside and rebaudioside on plaque-pH.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stevioside extract | Experimental | After measuring baseline plaque pH, the subjects rinsed for 1 minute with the solution containing Stevioside extract. Plaque pH was then measured at 5, 10, 15, 30, 45 and 60 min after the mouth rinse. |
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| Rebauside extract | Experimental | After measuring baseline plaque pH, the subjects rinsed for 1 minute with the solution containing Rebaudioside extract. Plaque pH was then measured at 5, 10, 15, 30, 45 and 60 min after the mouth rinse. |
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| Saccarosio | Sham Comparator | After measuring baseline plaque pH, the subjects rinsed for 1 minute with the sucrose solution. Plaque pH was then measured at 5, 10, 15, 30, 45 and 60 min after the mouth rinse. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Effect of Stevioside and Rebaudioside on plaque pH | Dietary Supplement | After measuring baseline plaque pH, the subjects rinsed for 1 minute with the sucrose solution. Plaque pH was then measured at 5, 10, 15, 30, 45 and 60 min after the mouth rinse. |
| Measure | Description | Time Frame |
|---|---|---|
| Plaque-pH modification | Plaque pH was measured at baseline and 5, 10, 15, 30, 45 and 60 minutes after each mouth rinse | 5, 10, 15, 30, 45, 60 minutes |
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Inclusion Criteria:
good general health, normal salivary secretion rate, normal buffer capacity
Exclusion Criteria:
systemic diseases, salivary secretion reduction, reduced buffer capacity
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| Name | Affiliation | Role |
|---|---|---|
| Laura Strohmenger, MD | WHO Collaborating Centre for Community Dentistry and Oral Epidemiology University of Milan | Study Chair |
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| ID | Term |
|---|---|
| D003731 | Dental Caries |
| ID | Term |
|---|---|
| D017001 | Tooth Demineralization |
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
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