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With the increase in the incidence of diabetes and obesity, among other artificial sweeteners the need of natural non-caloric sweetener with acceptable taste and without any adverse effects is demanding.So,the use of stevia presents beneficial effects to general and oral health and its properties could result potentially effective in the treatment of periodontal diseases.
Stevia is considered as a novel molecule, because it is 100% natural and non caloric sweetener, with more sweetness than sucrose, without any adverse effects. It also demonstrates multiple benefits like anti-plaque effect, anti-diabetic effect, anti-periodontophatics properties, anti-hypertensive properties, anti-cariogenic properties etc. There are many studies conducted on stevia in humans, which justifies my study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| stevia rebaudiana bertoni | Experimental | Randomly in all subjects one quadrant will be allotted as test site for placing stevia gel in the gingival sulcus having probing depth ≥ 5mm after performing thorough scaling and root planing. |
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| placebo | Placebo Comparator | Other quadrant will be allotted as a control site for placing placebo in the gingival sulcus having PD≥ 5mm after performing thorough scaling and root planing. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| stevia rebaudiana bertoni | Drug | Stevia has an anti-plaque effect because of its ability in decreasing the formation of bacterial insoluble polymers.It significantly decreases the production of TNF-R and IL-1a and slightly decreases the production of NO in stimulated cells with LPS and THP-1 showing its anti-inflammatory properties.These characteristics in combination with anti-diabetic properties could results in the effective treatment of periodontal diseases. |
| Measure | Description | Time Frame |
|---|---|---|
| Bio-marker (Ghrelin) levels in Gingival crevicular fluid. | GCF samples can be eluted from the strips by placing them in Eppendrof® tubes that contained 500 micro-litre of buffer and will be stored at -80℃ until analysis was done. The levels of GCF Ghrelin will be evaluated by using commercially available ELISA kit. | From baseline to 6-months. |
| Measure | Description | Time Frame |
|---|---|---|
| Probing depth | Probing depth (PD): Distance from the gingival margin to the bottom of gingival sulcus in mm. | From baseline to 6-months. |
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Inclusion Criteria:
Exclusion Criteria:
Subjects will be excluded from the study if they are using
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| R V Chandra, MDS;DNB;PHD | Contact | 9908183071 | viswachandra@hotmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| SVS Institute Of Dental Sciences | Recruiting | Hyderabad | Telangana | 509002 | India |
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| ID | Term |
|---|---|
| D010518 | Periodontitis |
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D044882 | Glucose Metabolism Disorders |
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| ID | Term |
|---|---|
| D035061 | Control Groups |
| ID | Term |
|---|---|
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
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one group of subjects receives intervention where as other group of subjects receive placebo.
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Both stevia gel and placebo syringes are masked from participants and investigators.
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| placebo | Other | A placebo without the active drug will be placed in the control sites. |
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| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D008722 | Methods |