Grape Polyphenol Kinetics in Humans

The objectives of this study are the following: 1) to confirm that the administration of grape juice, resveratrol, and grape seed polyphenol extract results in a similar plasma and urinary metabolic profile in aged humans compared to rats, 2) to confirm that a combined administration of grape juice, resveratrol, and grape seed polyphenol extract result in a similar plasma and urinary metabolic profile in adults with tendencies toward metabolic syndrome compared to non-obese healthy humans, and 3) to identify the anti-inflammatory effects of the combined administration of grape juice, resveratrol, and grape seed polyphenol extract.

Inclusion Criteria:

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Exclusion Criteria:

• Age <60 years at beginning of study
• Fasting glucose > 126 mg/dl
• Blood pressure > 160/100
• Fasting total blood cholesterol > 280 mg/dl
• Fasting triglycerides > 300 mg/dl
• Presence of kidney disease, liver disease, gout, hyperthyroidism, untreated or unstable hypothyroidism, certain cancers, gastrointestinal disease, pancreatic disease, other metabolic diseases, or malabsorption syndromes
• Presence of type 2 diabetes requiring the use of oral antidiabetic agents or insulin
• History of bariatric or certain other surgeries related to weight control
• Smokers or other tobacco users (during 6 months prior to the start of the study)
• Consumption of more than 3 servings of tea, wine, or grape juice per day
• Use of supplements containing grape extracts or products
• Use of antibiotics during the intervention or for 3 weeks prior to the intervention period
• History of eating disorders, dietary patterns, or supplement use which will interfere with the goal of the intervention
• Volunteers who have lost 10% of body weight within the last 4 months
• Volunteers who are unable or unwilling to give informed consent or communicate with study staff
• Volunteers who self-report of alcohol or substance abuse within the past 12 months and/or current acute treatment or rehabilitation program for these problems (long-term participation in Alcoholics Anonymous is not an exclusion)
• Other medical, psychiatric, or behavioral factors that in the judgment of the Principal Investigator may interfere with study participation or the ability to follow the intervention protocol