Grape and Pomegranate Polyphenols in Postprandial Glucose and Related Parameters

Acute Effects of Grape and Pomegranate Polyphenols as Modulators of Metabolic Syndrome in Humans

The aim of this is study is to evaluate the acute effect of grape and pomegranate polyphenols in the modulation of markers of metabolic syndrome. Most of the previous works about polyphenols have only considered a fraction of polyphenols, i.e., extractable polyphenols. As a consequence, an important amount of dietary polyphenols, the so-called non-extractable polyphenols are ignored. In contrast, the effect of both extractable and non-extractable polyphenols will be considered in this study. Furthermore, the effect of both polyphenols as present in the food matrix and metabolites derived from microbial fermentation will be evaluated.

Inclusion Criteria:

• Abdominal perimeter ≥102 cm. for male participants and ≥88 cm for female participants.
• Subjects presenting some or several of these characteristics will be prioritized:

Fasting glucose values between 110-128 mg/dL. Triglycerides = 150-195 mg/dL. HDL-cholesterol: < 50 mg/dL men, < 40 mg/dL women. Blood pressure: systolic > 130 mm Hg; diastolic > 85 mm Hg.

Exclusion Criteria:

• Subjects taking drugs for hyperglycaemia, hypertension or hypercholesterolaemia.
• Volunteers participating in other studies or weight loss plans.
• Pregnant or breastfeeding women.