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Randomized placebo-controlled crossover study during which participants undergo two different experimental days. The participants consume a red grape based- drink (polyphenols: 300 mg/100 ml and sugar: 9.8g/100 ml) or a placebo (no polyphenols and sugar: 9.8g/100 ml). After 3 hours they consume a test meal (905 kcal, 15% protein, 46% fat, 39% CHO). Blood samples are taken at fasting, over 3 hours after drink consumption and over 5 hours after the test meal to evaluate metabolic response. Fasting and 48h-urine are collected to evaluate bioavailability.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Polyphenol-rich drink | Experimental | The participants consume the polyphenol-rich drink. After 3 hours they consume a standard meal to evaluate whether the metabolic response may be influenced by polyphenols. |
|
| Placebo drink | Placebo Comparator | The participants consume the control drink.After 3 hours they consume a standard meal to evaluate the metabolic response after a placebo. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Standard meal | Other | The participants consume the drink, experimental or placebo drink. After 3 hours they consume a standard meal (905 kcal, 15% protein, 46% fat, 39% CHO). Blood samples are taken at fasting, over 3 hours after drink consumption and over 5 hours after the test meal to evaluate metabolic response. Fasting and 48h-urine are collected to evaluate bioavailability of polyphenol. |
| Measure | Description | Time Frame |
|---|---|---|
| Phenolic metabolites in urine | GCxGC-MS | 48 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Glucose response | Enzymatic colorimetric methods | 8 hours |
| Inflammation | Multiplex Detection Immunoassays | 8 hours |
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Inclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30573355 | Derived | Costabile G, Vitale M, Luongo D, Naviglio D, Vetrani C, Ciciola P, Tura A, Castello F, Mena P, Del Rio D, Capaldo B, Rivellese AA, Riccardi G, Giacco R. Grape pomace polyphenols improve insulin response to a standard meal in healthy individuals: A pilot study. Clin Nutr. 2019 Dec;38(6):2727-2734. doi: 10.1016/j.clnu.2018.11.028. Epub 2018 Dec 7. |
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|
| Oxidative stress (urinary isoprostanes) | EIA | 8 hours |
| Triglyceride response | Enzymatic colorimetric methods | 8 hours |