The Effects of Amino Acid Supplement During Acute Inflammation.

Metabolic Effects of Endotoxin Induced Acute Inflammation in Healthy Young Men With and Without Supplement of Amino Acids.

The purpose of the study is to investigate the metabolic effects during acute inflammation with and without the nutritional supplement of amino acids.

E. Coli Endotoxin (LPS, lipopolysaccharide) is used to initiate an inflammatory response.

The study is an interventional randomized placebo study including 8 healthy male subjects. Each subject participates 3 times (different days) and are given one of following interventions:

• Placebo (NaCl)
• Endotoxin, US standard reference E.Coli + Placebo (NaCl)
• Endotoxin, US standard reference E.Coli + Amino acids (intravenously)

It is our hypothesis that the nutritional intervention during acute inflammation plays an important role in lipid and protein metabolism.

Inclusion Criteria:

• male gender
• 20<BMI<30
• Age > 25 years old
• Written consent before starting the study

Exclusion Criteria:

• Allergy for soya products ore egg
• Diabetes
• Epilepsy
• Infection
• Immune defects
• Heart disease
• Dysregulated hypertension
• Participating in other trials using radioactive tracers or x-rays the last year.