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| ID | Type | Description | Link |
|---|---|---|---|
| 1-10-72-530-12 | Other Identifier | Regional Ethics Comite |
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The investigators hypothesize that the investigators can detect protein-sparing effects of administration of the ketone 3-hydroxybutyrate and free fatty acids during simulation of an acute inflammatory disease. The investigators use the infusion of endotoxin, US standard reference E.coli in healthy subjects as a model for inflammation / infection and to evaluate the effect on protein metabolism using different tracers and the investigators can measure the various intracellular signaling pathways of selected muscle and adipose tissue.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo (isotonic saline) | Placebo Comparator | Endotoxin + isotonic saline. Reference for model of acute inflammatory illness |
|
| Acipimox + Placebo (isotonic saline) | Experimental | Endotoxin + Acipimox + Placebo (isotonic saline). Intervention: blockage of endogenous lipolysis. |
|
| Acipimox + free fatty acids | Experimental | Endotoxin + Acipimox + free fatty acids. Intervention: free fatty acids |
|
| Acipimox + 3-hydroxybutyrate | Experimental | Endotoxin + Acipimox + 3-hydroxybutyrate. Intervention: 3-hydroxybutyrate |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Endotoxin, US standard reference E.coli | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Protein metabolism | Measurements of protein oxidation during intervention using radioactive tracer techniques. | 6 hours intervention period |
| Measure | Description | Time Frame |
|---|---|---|
| Activated intracellular signalling pathways | Measurements on biopsies from muscle and fatty tissue taken on day of study | study day |
| Measure | Description | Time Frame |
|---|---|---|
| Other systemic metabolic effects | 6 hours of intervention |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Niels Møller, Professor | Institute of Clinical Medicine, Aarhus University, Denmark. Department of Internal Medicin and Endocrinology, Aarhus university hospital, Aarhus, Denmark. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical Research Laboratory, Department of Internal Medicine and Endocrinology | Aarhus C | 8000 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30239561 | Derived | Thomsen HH, Rittig N, Johannsen M, Moller AB, Jorgensen JO, Jessen N, Moller N. Effects of 3-hydroxybutyrate and free fatty acids on muscle protein kinetics and signaling during LPS-induced inflammation in humans: anticatabolic impact of ketone bodies. Am J Clin Nutr. 2018 Oct 1;108(4):857-867. doi: 10.1093/ajcn/nqy170. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Feb 20, 2025 | |
| Reset | Mar 11, 2025 | |
| Release | May 23, 2025 | |
| Reset | Jun 11, 2025 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Feb 20, 2025 | Mar 11, 2025 | |||
| May 23, 2025 |
| ID | Term |
|---|---|
| D018746 | Systemic Inflammatory Response Syndrome |
| D018805 | Sepsis |
| D005334 | Fever |
| ID | Term |
|---|---|
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012769 | Shock |
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| ID | Term |
|---|---|
| D004731 | Endotoxins |
| ID | Term |
|---|---|
| D001427 | Bacterial Toxins |
| D014118 | Toxins, Biological |
| D001685 | Biological Factors |
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| Jun 11, 2025 |
| D007239 |
| Infections |
| D001832 | Body Temperature Changes |
| D012816 | Signs and Symptoms |