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The aim of the study is to isolate the direct effects of endotoxin on glucose, lipid and protein metabolism. Eight healthy volunteers are enrolled. The hypothesis is that endotoxin will induce insulin resistance, lypolysis and proteolysis acutely.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Endotoxin | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| USP endotoxin | Biological | Continuous intra-arterial infusion |
|
| Measure | Description | Time Frame |
|---|---|---|
| glucose concentration | 360 minutes observation |
| Measure | Description | Time Frame |
|---|---|---|
| Regional arteriovenous amino-acid balance | measured at t=180 and 360 minutes | |
| Intra-cellular insulin signaling | measured at t=0, 120, and, 210 minutes | |
| Regional arteriovenous lipid balance |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mads Buhl, M.D. | Medical Department M (Endocrinology and Diabetes), Århus University Hospital, Denmark | Principal Investigator |
| Niels Moller, M.D., professor, Dmsc | Medical Department M (Endocrinology and Diabetes), Aarhus University Hospital, Denmark | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Medical Research Laboratories, Dept. M, Aarhus University Hospital | Aarhus | 8000 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23543661 | Derived | Buhl M, Bosnjak E, Vendelbo MH, Gjedsted J, Nielsen RR, K-Hafstrom T, Vestergaard ET, Jessen N, Tonnesen E, Moller AB, Pedersen SB, Pilegaard H, Bienso RS, Jorgensen JO, Moller N. Direct effects of locally administered lipopolysaccharide on glucose, lipid, and protein metabolism in the placebo-controlled, bilaterally infused human leg. J Clin Endocrinol Metab. 2013 May;98(5):2090-9. doi: 10.1210/jc.2012-3836. Epub 2013 Mar 29. |
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| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| measured at t=180 and 360 minutes |