Peripheral Effects of Endotoxin on Insulin Resistance

The Effect of Regional Inflammation on Metabolism and Insulin Sensitivity in the Lower Extremity.

The aim of the study is to isolate the direct effects of endotoxin on glucose, lipid and protein metabolism. Eight healthy volunteers are enrolled. The hypothesis is that endotoxin will induce insulin resistance, lypolysis and proteolysis acutely.

Inclusion Criteria:

1. Normal health
2. 22 < BMI < 28
3. Written Informed Concent

Exclusion Criteria:

1. Any disease
2. Any use of medication
3. Recent immobilization of a lower extremity