Comparison Between Cisatracurium and Rocuronium in Terms of Recovery of the Muscular Strength in the Postoperative Phase After Surgery and General Anaesthesia

Assessment of Post-operative Residual Curarization (PORC) Incidence in Patients Undergoing Surgery With General Anaesthesia; Comparison Between Cisatracurium and Rocuronium. A Randomised, Single-blind Phase 4 Study.

The purpose of this study is to determine the incidence of post-operative residual curarization in our patients and to determine if Cisatracurium and Rocuronium behave differently from each other in terms of residual curarization.

Inclusion Criteria:

• general anaesthesia with need to use of neuromuscular-blocking agents
• awakening and extubation of the patient in the operating room and permanence in the PACU for at least 60 minutes
• age 18-80
• surgical operations lasting at least 1 hour
• ASA class I-III
• possibility to apply TOF-monitoring with thumb-acceleromyography
• women of childbearing age not using contraceptives
• women of childbearing age using contraceptives

Exclusion Criteria:

• subjects unable to give a valid consent
• patients in emergency situations
• patients not awakened and not extubated in the operating room
• age above 80 years or under 18 years
• surgical operations lasting less than an hour
• ASA class IV
• impossibility to apply and/or perform TOF-monitoring
• neuromuscular diseases
• intake of therapies interfering with the neuromuscular function
• patients having contraindications for either studied drug
• pregnant women
• women who are breast-feeding