Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The investigators investigated whether laparoscopic versus open surgical approaches affected the pharmacokinetic and pharmacodynamic of a single bolus dose of rocuronium or cisatracurium.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| laparoscopic operation on rocuronium | Experimental | according different surgical type, all patients were divided into 2 groups: the laparoscopic surgery group and open surgery group.Each group were randomly assigned to the rocuronium group and cisatracurium group. |
|
| laparoscopic operation on cisatracurium | Experimental | according different surgical type, all patients were divided into 2 groups: the laparoscopic surgery group and open surgery group.Each group were randomly assigned to the rocuronium group and cisatracurium group. |
|
| conventional open surgery on rocuronium | Experimental | according different surgical type, all patients were divided into 2 groups: the laparoscopic surgery group and open surgery group.Each group were randomly assigned to the rocuronium group and cisatracurium group. |
|
| conventional open surgery on cisatracurium | Experimental | according different surgical type, all patients were divided into 2 groups: the laparoscopic surgery group and open surgery group.Each group were randomly assigned to the rocuronium group and cisatracurium group. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| rocuronium | Drug | Rocuronium 0.6 mg.kg-1 was administered within 5 s as an intravenous bolus |
|
| Measure | Description | Time Frame |
|---|---|---|
| the blood flow in the right and middle hepatic veins | Measurements of the blood flow in the right and middle hepatic veins were performed at baseline and 1,5, 10, 20, 30min after insufflation of carbon dioxide or incise the skin as well as 1 and 5 min after deflation or close the wound. | up to 9 months |
| Measure | Description | Time Frame |
|---|---|---|
| the plasma Concentration of rocuronium and cisatracurium | Venous blood samples (3 ml) were taken 2 min prior to and at 5,30, 60 min following administration of rocuronium/cisatracurium.The aim of the present was to study the blood concentration of rocuronium/cisatracurium in laparoscopic surgery compared with conventional open gynaecological surgery | up to 9 months |
| Measure | Description | Time Frame |
|---|---|---|
| pharmacodynamic comparison of rocuronium and cisatracurium | This study was undertaken to investigate the duration of action of 0.9 mg.kg-1 rocuronium or cisatracurium 0.15 mg.kg-1 administered during laparoscopic surgery compared with conventional open gynaecological surgery.Adductor pollicis train-of-four responses following ulnar nerve stimulation were monitored with mechanomyography.We recorded the time from the end of injection of rocuronium or cisatracurium to time to recovery of T1, and to recovery to 5% and 25% of baseline height |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Shaoqiang Huang, doctor | Obstetrics and Gynecology,Fudan University | Principal Investigator |
Not provided
Not provided
| ID | Term |
|---|---|
| D000077123 | Rocuronium |
| C101584 | cisatracurium |
| ID | Term |
|---|---|
| D000732 | Androstanols |
| D000731 | Androstanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| cisatracurium | Drug | cisatracurium 0.15mg.kg-1 was administered within 5 s as an intravenous bolus |
|
| up to 9 months |
| D011083 |
| Polycyclic Compounds |