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| Name | Class |
|---|---|
| Ruijin Hospital | OTHER |
| RenJi Hospital | OTHER |
| Shanghai Zhongshan Hospital | OTHER |
| The First Affiliated Hospital of Guangzhou Medical University |
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The purpose of this study is to determine the incidence of residual curarization in PACU and relevant risk factors.
In the last twenty years, residual curarization in PACU (Post Anesthesia Care Unit) has become a common problem in clinical practice and poses high risk to patients. The residual curarization incidence of Neuromuscular blocking agents (NMBA) varies very much between different studies. These differences indicates the necessity of further study. In China, there is no common view of the harmfulness of residual curarization and its complications. The consensus on the necessity of neuromuscular transmission monitoring and neuromuscular blockade antagonist has not been reached yet. There is also no similar large-scale survey in China. In this case, the investigators conduct this large scale multicentre study, which is designed to learn the incidence of residual curarization and its complications. Further analysis of risk factors will also been made. All these efforts are hoped to fill the data gap and provide reliable evidences for rational use of NMBA.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vecuronium Bromide | Active Comparator | Patients who will be performed general anesthesia and tracheal intubation. Vecuronium will be used during surgery and tracheal extubation is scheduled when surgery is over. |
|
| cisatracurium | Active Comparator | Patients who will be performed general anesthesia and tracheal intubation. Cisatracurium will be used during surgery and tracheal extubation is scheduled when surgery is over. |
|
| rocuronium | Active Comparator | Patients who will be performed general anesthesia and tracheal intubation. Rocuronium will be used during surgery and tracheal extubation is scheduled when surgery is over. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vecuronium Bromide | Drug | Administrative protocol of Vecuronium Bromide is determined by each caregiver's clinical experience. |
|
| Measure | Description | Time Frame |
|---|---|---|
| incidence of TOFr<0.9 | Once tracheal extubation is performed after the surgery is over, monitor the neuromuscular transmission function (TOF ratio) immediately. | From tracheal extubation to 1 minute after extubation |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of TOFr<0.9 | When patients arrive at PACU(an expected average of 15 minutes after surgery is over), monitor the neuromuscular transmission function (TOF ratio) immediately | One minute after arriving at PACU |
| Incidence of TOFr<0.7 |
| Measure | Description | Time Frame |
|---|---|---|
| any sign of residual curarization (listed in description below) | Sign of residual curarization :
| First 24h after surgery |
| pulmonary complications (See description) |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xinmin Wu, Doctor | Contact | +86 13910616740 | xmwu2784@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Xinmin Wu, Doctor | Peking University First Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chinese PLA General Hospital | Recruiting | Beijing | Beijing Municipality | 100000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16428537 | Background | Cammu G, De Witte J, De Veylder J, Byttebier G, Vandeput D, Foubert L, Vandenbroucke G, Deloof T. Postoperative residual paralysis in outpatients versus inpatients. Anesth Analg. 2006 Feb;102(2):426-9. doi: 10.1213/01.ane.0000195543.61123.1f. | |
| 19910616 | Background | Naguib M, Kopman AF, Lien CA, Hunter JM, Lopez A, Brull SJ. A survey of current management of neuromuscular block in the United States and Europe. Anesth Analg. 2010 Jul;111(1):110-9. doi: 10.1213/ANE.0b013e3181c07428. Epub 2009 Nov 12. |
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| OTHER |
| West China Hospital | OTHER |
| Eastern Hepatobiliary Surgery Hospital | OTHER |
| Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | OTHER |
| Zhujiang Hospital | OTHER |
| Chinese PLA General Hospital | OTHER |
| First Affiliated Hospital, Sun Yat-Sen University | OTHER |
| The First Affiliated Hospital of Zhengzhou University | OTHER |
| Tianjin Medical University General Hospital | OTHER |
| Xiangya Hospital of Central South University | OTHER |
| Central South University | OTHER |
| Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | OTHER |
| First Affiliated Hospital of Xinjiang Medical University | OTHER |
| Peking Union Medical College Hospital | OTHER |
| First Affiliated Hospital of Zhejiang University | OTHER |
| China Medical University Hospital | OTHER |
| Hebei Medical University Fourth Hospital | OTHER |
| Tongji Hospital | OTHER |
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| Rocuronium | Drug | Administrative protocol of rocuronium is determined by each caregiver's clinical experience. |
|
|
| Cisatracurium | Drug | Administrative protocol of cisatracurium is determined by each caregiver's clinical experience |
|
|
Once tracheal extubation is performed after the surgery is over, monitor the neuromuscular transmission function (TOF ratio) immediately.
| From tracheal extubation to 1 minute after extubation |
| Incidence of TOFr<0.7 | When patients arrive at PACU(an expected average of 15 minutes after surgery is over), monitor the neuromuscular transmission function (TOF ratio) immediately | One minute after arriving at PACU |
pulmonary complications
|
| participants will be followed for the duration of hospital stay, an expected average of one week |
| Peking Union Medical College Hospital | Recruiting | Beijing | Beijing Municipality | 100000 | China |
|
| Peking University First Hospital | Recruiting | Beijing | Beijing Municipality | 100034 | China |
|
| First Affiliated Hospital, Sun Yat-Sen University | Recruiting | Guangzhou | Guangdong | 510000 | China |
|
| The First Affiliated Hospital of Guangzhou Medical University | Recruiting | Guangzhou | Guangdong | 510000 | China |
|
| Zhujiang Hospital Southern Medical University | Recruiting | Guangzhou | Guangdong | 510000 | China |
|
| Hebei Medical University Fourth Hospital | Recruiting | Shijiazhuang | Hebei | 050000 | China |
|
| The First Affiliated Hospital of Zhengzhou University | Recruiting | Zhengzhou | Henan | 450000 | China |
|
| Tongji Hospital, Tongji Medical College of HUST | Recruiting | Wuhan | Hubei | 430000 | China |
|
| Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Recruiting | Wuhan | Hubei | 430000 | China |
|
| The Second Xiangya Hospital of Central South University | Recruiting | Changsha | Hunan | 410000 | China |
|
| Xiangya Hospital of Central South University | Recruiting | Changsha | Hunan | 410000 | China |
|
| China Medical University Hospital | Recruiting | Shenyang | Liaoning | 110000 | China |
|
| Eastern Hepatobiliary Surgery Hospital | Recruiting | Shanghai | Shanghai Municipality | 200000 | China |
|
| RenJi Hospital | Recruiting | Shanghai | Shanghai Municipality | 200000 | China |
|
| Ruijin Hospital | Recruiting | Shanghai | Shanghai Municipality | 200000 | China |
|
| Shanghai First People's Hospital | Recruiting | Shanghai | Shanghai Municipality | 200000 | China |
|
| Shanghai Zhongshan Hospital | Recruiting | Shanghai | Shanghai Municipality | 200000 | China |
|
| West China Hospital, Sichuan University | Recruiting | Chengdu | Sichuan | 610000 | China |
|
| Tianjin Medical University General Hospital | Recruiting | Tianjin | Tianjin Municipality | 300000 | China |
|
| The First Teaching Hospital of Xinjiang Medical University | Withdrawn | Ürümqi | Xinjiang | 830000 | China |
| The First Affiliated Hospital Of College of Medicine, Zhejiang University | Recruiting | Hangzhou | Zhejiang | 310000 | China |
|
| 17307778 | Background | Naguib M, Kopman AF, Ensor JE. Neuromuscular monitoring and postoperative residual curarisation: a meta-analysis. Br J Anaesth. 2007 Mar;98(3):302-16. doi: 10.1093/bja/ael386. |
| 11284816 | Background | Hayes AH, Mirakhur RK, Breslin DS, Reid JE, McCourt KC. Postoperative residual block after intermediate-acting neuromuscular blocking drugs. Anaesthesia. 2001 Apr;56(4):312-8. doi: 10.1046/j.1365-2044.2001.01921.x. |
| 16183681 | Background | Baillard C, Clec'h C, Catineau J, Salhi F, Gehan G, Cupa M, Samama CM. Postoperative residual neuromuscular block: a survey of management. Br J Anaesth. 2005 Nov;95(5):622-6. doi: 10.1093/bja/aei240. Epub 2005 Sep 23. |
| 11999596 | Background | Cammu G, de Baerdemaeker L, den Blauwen N, de Mey JC, Struys M, Mortier E. Postoperative residual curarization with cisatracurium and rocuronium infusions. Eur J Anaesthesiol. 2002 Feb;19(2):129-34. doi: 10.1017/s0265021502000236. |
| 10793602 | Background | Baillard C, Gehan G, Reboul-Marty J, Larmignat P, Samama CM, Cupa M. Residual curarization in the recovery room after vecuronium. Br J Anaesth. 2000 Mar;84(3):394-5. doi: 10.1093/oxfordjournals.bja.a013445. |
| 15920224 | Background | Murphy GS, Szokol JW, Marymont JH, Franklin M, Avram MJ, Vender JS. Residual paralysis at the time of tracheal extubation. Anesth Analg. 2005 Jun;100(6):1840-1845. doi: 10.1213/01.ANE.0000151159.55655.CB. |
| 12717123 | Background | Debaene B, Plaud B, Dilly MP, Donati F. Residual paralysis in the PACU after a single intubating dose of nondepolarizing muscle relaxant with an intermediate duration of action. Anesthesiology. 2003 May;98(5):1042-8. doi: 10.1097/00000542-200305000-00004. |
| 19468024 | Background | Srivastava A, Hunter JM. Reversal of neuromuscular block. Br J Anaesth. 2009 Jul;103(1):115-29. doi: 10.1093/bja/aep093. Epub 2009 May 24. |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D055191 | Delayed Emergence from Anesthesia |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D014673 | Vecuronium Bromide |
| D000077123 | Rocuronium |
| C101584 | cisatracurium |
| ID | Term |
|---|---|
| D000732 | Androstanols |
| D000731 | Androstanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
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