Effect of Diet Composition on Weight Change and Metabolic Parameters | NCT01642849 | Trialant

Unknown statusInterventionalNot ApplicableUpdated Jul 17, 2012

Effect of Diet Composition on Weight Change and Metabolic Parameters

Overview

Key facts that identify this study and show where it stands today.

ClinicalTrials.gov ID: NCT01642849
Lead Sponsor: University of TennesseeOTHER
Overall Status: Unknown status
Study Type: Interventional
Phase: Not Applicable
Enrollment: 24Estimated
Last Update Posted: Jul 17, 2012Estimated
Start Date: Jan 2009
Primary Completion Date: Jan 2013Estimated
Completion Date: Jun 2013Estimated

Description

What the study is about and why it is being run, in the researchers' own words.

Official Title: Effect of Diet Composition on Weight Change and Metabolic Parameters
Brief Summary: This study will assess the effect of high protein (HP) and high carbohydrate (HC) diets on weight loss and other metabolic parameters.

Rationale: The prevalence of obesity is on the rise in the US. The health hazards of obesity have been well established. The detrimental effects of obesity on cardiovascular, metabolic and psychological parameters as well as the excess cost to the national health budget are astounding. One way of treatment and prevention of obesity has been the use of diet and exercise. In the absence of well-established superiority of one diet over another, different scientifically unproven diets are in common use. A palatable diet providing satiety as well as all essential nutrients may go a long way in treating over-weight individuals. Another factor has been the long-term adherence to such weight loss regimens, which in general have been poor. Protein diets have been known to provide greater satiety and reduced energy intake than carbohydrate diets, but definite long-term studies are sparse. For this study the investigators will recruit and study 24 normal, pre-menopausal obese women (12 on HP diet and 12 on HC diet), and compare their weight loss and changes in metabolic parameters between the two diets.

Conditions

The medical conditions and diseases this study investigates.

Obesity
Inflammation

Interventions

The treatments and procedures being evaluated in this study.

high protein diet
high carbohydrate diet

Participation

Who can join this study and the criteria used to decide.

Ages Eligible for Study: Adult (18-64)
Sexes Eligible for Study: Female
Accepts Healthy Volunteers: Yes
Eligibility Criteria: Inclusion Criteria:

Age range 20 yrs to 50 yrs,

BMI > 30 kg/m2 to < 55 kg/m2

Fasting glucose < 110 mg/dl and 120 minute OGTT < 170 mg/dl glucose

Design

How the study is designed and how its participant groups are organized.

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Single

Contacts

The people to reach with questions about this study or how to join it.

Frankie B Stentz, M.S., Ph.D.Contact

fstentz@uthsc.edu901-448-5803

Locations

Where the study is run and whether each site is currently recruiting.

University of Tennessee Health Science CenterRecruiting

Memphis, Tennessee 38163, United States

Collaborators

The organizations and people involved in this study.

Lead Sponsor: University of TennesseeOTHER

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Other registered studies that closely resemble this one.

Detailed Description

Population: Recruit and study 24 pre-menopausal women with the following inclusion criteria:

Age range 20 yrs to 50 yrs, BMI > 30 kg/m2 to < 55 kg/m2 Fasting glucose < 110 mg/dl and 120 minute OGTT < 170 mg/dl glucose Design: The study is designed to determine the follow

To compare the effects of high protein (HP) versus high carbohydrate (HC) diet during energy restriction on weight loss, body composition (lean and fat body mass) and bone mineral density in a free living out patient setting.

To assess the effects of HP versus HC diets on metabolic parameters including insulin sensitivity, protein and muscle break down, lipoprotein metabolism and basal metabolic rate.

Procedures: SCREENING VISIT 1:Individuals fulfilling the inclusion and exclusion criteria will be invited for the first screening visit (VS1). A brief study overview will be given along with a brief history and physical examination, height and weight measurements and blood drawn for chemistry profile and and Oral Glucose Tolerance Test (OGTT) to determine normal glucose handling.

SCREENING VISIT 2 (VS2):Individuals fulfilling all the criteria will be contacted and invited for a second screening visit (VS2). Block food frequency questionnaire to assess baseline dietary profile will be given along with a pre-study orientation with the help of a nutritionist.

SCREENING VISIT 3 (VS3): At the final screening visit (VS3) the food diary will be reviewed. Individuals will be randomized into one of the two diet groups using a randomization table. Participants will be asked to participate in the additional studies of euglycemic hyperinsulinemic clamp and indirect calorimetry.

Study participants will either follow a HP or a HC diet for 6 months, where all food is supplied to them. Randomization will be performed using a randomization table. HP diet will be based on 30% Kcals from protein, 40% Kcals from carbohydrate (CHO) and 30% Kcals from fat. In contrast, HC diet will comprise 15% Kcals from protein, 55% Kcals from CHO and 30% Kcals from fat. Subjects will come in weekly for their food pick up and weight checks.