Diet Composition - Metabolic Regulation and Long-term Compliance

Diet Composition - Metabolic Regulation and Long-term Compliance

This study will compare a high-protein/low-carbohydrate diet (modified paleolithic diet, MPD) with a diet high in slow carbohydrates (Nordic Nutrition Recommendations, NNR). The diets will be compared with respect effects on weight reduction, metabolic regulation, and long-term compliance to the diet regimes. Seventy-two postmenopausal overweight healthy women have been recruited and will be followed for two years.

The following variables will be studied:

• Anthropometry
• DEXA
• OGTT
• Liver fat content measured with 1H-MRS
• Hepatic 11β-HSD1 activity, measured with cortisone/cortisol conversion test

Inclusion Criteria:

• Female
• Postmenopausal
• BMI>28

Exclusion Criteria:

• Disease
• Gravidity
• Smoking
• Prescribed medication