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| ID | Type | Description | Link |
|---|---|---|---|
| 334602 Preobe Follow Up | Other Grant/Funding Number | Abbot Laboratories SA/General Foundation University of Granada - Enterprise |
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| Name | Class |
|---|---|
| Ministerio de EconomÃa y Competitividad, Spain | OTHER_GOV |
| Abbott | INDUSTRY |
| Scottish Government NuGO EU Project | UNKNOWN |
| University of Barcelona |
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In the PREOBE projects it is aimed to obtain genetic and biochemical biomarkers for the programming of obesity in early stages of life. This can be achieved by studying pregnant women with normal weight, overweight, obesity and gestational diabetes, and by analyzing how these conditions could impact on fetal growth and development; the risk of obesity in the offspring during the first 3 years of life will be also assessed (genetic polymorphisms of the most recognized genes related to obesity; gene expression of placental biomarkers indicators of early programming, polyunsaturated fatty acids, immunological and pro-inflammatory markers, analysis of endogenous and exogenous lipid peroxidation, allergies & neurodevelopmental assessment...). Moreover, the interaction of pathological maternal conditions with confounder factors that could have a role in the proposed outcomes will be also studied (maternal and child dietary intake, medical history and socioeconomic & environmental factors).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group | women with 18.5 > BMI < 25 | ||
| Pregnant women with overweight | BMI≥25 before the pregnancy | ||
| Pregnant women with obesity | BMI≥30 before the pregnancy | ||
| Pregnant women with gestational diabetes | Gestational diabetes |
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| Measure | Description | Time Frame |
|---|---|---|
| Long-term evidence of early human programming of obesity measured by nutritional biomarkers, and the offspring growth and development. | Participants will be followed for the duration of the study, an expected average of 6 years | |
| Long-term evidence of early human programming of obesity measured by genetic biomarkers, and the offspring growth and development. | Participants will be followed for the duration of the study, an expected average of 6 years | |
| Long-term evidence of early human programming of obesity measured biochemical perinatal biomarkers, and the offspring growth and development. | Participants will be followed for the duration of the study, an expected average of 6 years |
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Inclusion Criteria:
Exclusion Criteria:
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A total of 350 pregnant women aged between 18 and 42, with singleton pregnancies, were recruited at 12 weeks of pregnancy at the Clinical University Hospital 'San Cecilio' and "Mother-Infant" Hospital in the city of Granada, Spain
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Cristina Campoy, Professor, MD | Contact | 0034 629308695 | ccampoy@ugr.es |
| Name | Affiliation | Role |
|---|---|---|
| Cristina Campoy, Professor, MD | Universidad de Granada | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Pediatrics, School of Medicine, University of Granada | Recruiting | Granada | 18012 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20205964 | Result | Santacruz A, Collado MC, Garcia-Valdes L, Segura MT, Martin-Lagos JA, Anjos T, Marti-Romero M, Lopez RM, Florido J, Campoy C, Sanz Y. Gut microbiota composition is associated with body weight, weight gain and biochemical parameters in pregnant women. Br J Nutr. 2010 Jul;104(1):83-92. doi: 10.1017/S0007114510000176. Epub 2010 Mar 8. | |
| 19132267 |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| OTHER |
| ICTAN-CSIC - Madrid - Spain | UNKNOWN |
| Ludwig-Maximilians - University of Munich | OTHER |
| University of Nottingham | OTHER |
| University of Aberdeen | OTHER |
| Andalusian Agency of Knowledge | OTHER_GOV |
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Maternal blood and blood from the umbilical cord, serum, plasma, placental tissue, placental tissue treated with RNAlater, saliva, oral mucosa, urine, faeces, human milk
| Campoy C, Martin-Bautista E, Garcia-Valdes L, Florido J, Agil A, Lorente JA, Marcos A, Lopez-Sabater MC, Miranda-Leon T, Sanz Y, Molina-Font JA; grupo PREOBE. [Study of maternal nutrition and genetic on the foetal adiposity programming (The PREOBE study)]. Nutr Hosp. 2008 Nov-Dec;23(6):584-90. Spanish. |
| 38052208 | Derived | Cerdo T, Ruiz-Rodriguez A, Acuna I, Torres-Espinola FJ, Menchen-Marquez S, Gamiz F, Gallo M, Jehmlich N, Haange SB, von Bergen M, Campoy C, Suarez A. Infant gut microbiota contributes to cognitive performance in mice. Cell Host Microbe. 2023 Dec 13;31(12):1974-1988.e4. doi: 10.1016/j.chom.2023.11.004. Epub 2023 Dec 4. |
| 26931143 | Derived | Berglund SK, Garcia-Valdes L, Torres-Espinola FJ, Segura MT, Martinez-Zaldivar C, Aguilar MJ, Agil A, Lorente JA, Florido J, Padilla C, Altmae S, Marcos A, Lopez-Sabater MC, Campoy C; PREOBE team. Maternal, fetal and perinatal alterations associated with obesity, overweight and gestational diabetes: an observational cohort study (PREOBE). BMC Public Health. 2016 Mar 1;16:207. doi: 10.1186/s12889-016-2809-3. |
| 26208217 | Derived | Torres-Espinola FJ, Berglund SK, Garcia-Valdes LM, Segura MT, Jerez A, Campos D, Moreno-Torres R, Rueda R, Catena A, Perez-Garcia M, Campoy C; PREOBE team. Maternal Obesity, Overweight and Gestational Diabetes Affect the Offspring Neurodevelopment at 6 and 18 Months of Age--A Follow Up from the PREOBE Cohort. PLoS One. 2015 Jul 24;10(7):e0133010. doi: 10.1371/journal.pone.0133010. eCollection 2015. |
| 26025336 | Derived | Torres-Espinola FJ, Altmae S, Segura MT, Jerez A, Anjos T, Chisaguano M, Carmen Lopez-Sabater M, Entrala C, Alvarez JC, Agil A, Florido J, Catena A, Perez-Garcia M, Campoy C. Maternal PPARG Pro12Ala polymorphism is associated with infant's neurodevelopmental outcomes at 18 months of age. Early Hum Dev. 2015 Aug;91(8):457-62. doi: 10.1016/j.earlhumdev.2015.05.001. Epub 2015 May 26. |
| 26021978 | Derived | Uhl O, Demmelmair H, Segura MT, Florido J, Rueda R, Campoy C, Koletzko B. Effects of obesity and gestational diabetes mellitus on placental phospholipids. Diabetes Res Clin Pract. 2015 Aug;109(2):364-71. doi: 10.1016/j.diabres.2015.05.032. Epub 2015 May 16. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D004700 | Endocrine System Diseases |