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| ID | Type | Description | Link |
|---|---|---|---|
| R01DK076648 | U.S. NIH Grant/Contract | View source | |
| UL1TR001082 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | NIH |
| National Center for Advancing Translational Sciences (NCATS) | NIH |
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The purpose of this study is to establish and follow longitudinally a cohort of ethnically diverse pregnant women and their offspring, in order to explore the hypothesis that fetal over-nutrition is associated with obesity, metabolic, and cardiovascular abnormalities in the offspring.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pregnant women and their offspring | Ethnically diverse pregnant women and their offspring |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Maternal factors | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Fat mass | Body composition assessed via air displacement plethysmography to calculate fat mass and fat-free mass. | Birth |
| Fat mass | Body composition assessed via air displacement plethysmography to calculate fat mass and fat-free mass. | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Fat mass | Body composition assessed via air displacement plethysmography to calculate fat mass and fat-free mass. | 5 months |
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Inclusion Criteria:
Exclusion Criteria:
Multiple gestation
Preexisting
Previous premature delivery prior to 25 weeks gestation or fetal demise
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Participants were recruited from prenatal obstetrics clinics at the University of Colorado Hospital outpatient pavilion.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dana Dabelea, MD, PhD | Contact | 303-724-4414 | Dana.Dabelea@ucdenver.edu |
| Name | Affiliation | Role |
|---|---|---|
| Dana Dabelea, MD, PhD | University of Colorado, Denver | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Colorado Denver | Recruiting | Aurora | Colorado | 80045 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42104380 | Derived | Francis EC, Boyle KE, Gyllenhammer LE, Dabelea D, Jansson T, Perng W. Placental insulin-mTOR and stress-inflammatory signaling patterns are associated with childhood adiposity. BMC Med. 2026 May 8;24(1):370. doi: 10.1186/s12916-026-04896-8. | |
| 37694587 | Derived | Buck KE, Dhaliwal SK, Dabelea D, Perng W. Association of maternal psychosocial stress with newborn body composition in the Healthy Start study. J Dev Orig Health Dis. 2023 Oct;14(5):576-583. doi: 10.1017/S2040174423000223. Epub 2023 Sep 11. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| 37321280 | Derived | Dhaliwal SK, Dabelea D, Lee-Winn AE, Crume T, Wilkening G, Perng W. Maternal psychosocial stress during pregnancy and offspring neurobehavioral outcomes during early childhood in the Healthy Start Study. Ann Epidemiol. 2023 Oct;86:16-24.e3. doi: 10.1016/j.annepidem.2023.06.001. Epub 2023 Jun 14. |
| 36055960 | Derived | Cohen CC, Harrall KK, Gilley SP, Perng W, Sauder KA, Scherzinger A, Shankar K, Sundaram SS, Glueck DH, Dabelea D. Body composition trajectories from birth to 5 years and hepatic fat in early childhood. Am J Clin Nutr. 2022 Oct 6;116(4):1010-1018. doi: 10.1093/ajcn/nqac168. |
| 34850052 | Derived | Francis EC, Dabelea D, Boyle KE, Jansson T, Perng W. Maternal Diet Quality Is Associated with Placental Proteins in the Placental Insulin/Growth Factor, Environmental Stress, Inflammation, and mTOR Signaling Pathways: The Healthy Start ECHO Cohort. J Nutr. 2022 Mar 3;152(3):816-825. doi: 10.1093/jn/nxab403. |
| 29217099 | Derived | Moore BF, Sauder KA, Starling AP, Hebert JR, Shivappa N, Ringham BM, Glueck DH, Dabelea D. Proinflammatory Diets during Pregnancy and Neonatal Adiposity in the Healthy Start Study. J Pediatr. 2018 Apr;195:121-127.e2. doi: 10.1016/j.jpeds.2017.10.030. Epub 2017 Dec 6. |
| 28659296 | Derived | Perng W, Ringham BM, Glueck DH, Sauder KA, Starling AP, Belfort MB, Dabelea D. An observational cohort study of weight- and length-derived anthropometric indicators with body composition at birth and 5 mo: the Healthy Start study. Am J Clin Nutr. 2017 Aug;106(2):559-567. doi: 10.3945/ajcn.116.149617. Epub 2017 Jun 28. |
| 26631736 | Derived | Boyle KE, Patinkin ZW, Shapiro AL, Baker PR 2nd, Dabelea D, Friedman JE. Mesenchymal Stem Cells From Infants Born to Obese Mothers Exhibit Greater Potential for Adipogenesis: The Healthy Start BabyBUMP Project. Diabetes. 2016 Mar;65(3):647-59. doi: 10.2337/db15-0849. Epub 2015 Dec 2. |
| 25646327 | Derived | Starling AP, Brinton JT, Glueck DH, Shapiro AL, Harrod CS, Lynch AM, Siega-Riz AM, Dabelea D. Associations of maternal BMI and gestational weight gain with neonatal adiposity in the Healthy Start study. Am J Clin Nutr. 2015 Feb;101(2):302-9. doi: 10.3945/ajcn.114.094946. Epub 2014 Dec 3. |
| 25574704 | Derived | Crume TL, Shapiro AL, Brinton JT, Glueck DH, Martinez M, Kohn M, Harrod C, Friedman JE, Dabelea D. Maternal fuels and metabolic measures during pregnancy and neonatal body composition: the healthy start study. J Clin Endocrinol Metab. 2015 Apr;100(4):1672-80. doi: 10.1210/jc.2014-2949. Epub 2015 Jan 9. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |