Analgesic Efficacy of Nefopam in Patients Undergoing Kidney Transplantation

Analgesic Efficacy of Nefopam in Patients Undergoing Kidney Transplantation : Randomized Controlled Study

The investigators examined the efficacy of nefopam in patients undergoing kidney transplantation.

Drug combination are frequently used to relieve postoperative pain. Nefopam can inhibit serotonin, dopamine, and norepinephrine reuptake through central mechanisms. Several studies have demonstrated analgesic efficacy of nefopam in the postoperative period. The purpose of this study is to ascertain the analgesic effect and tolerance of intravenous nefopam in combination with fentanyl based patient-controlled analgesia after kidney transplantation.

Inclusion Criteria:

• elective living donor kidney transplantation

Exclusion Criteria:

• pre-operative tachycardia (> 100bpm)
• liver dysfunction
• severe cardiac disease
• body mass index ≥ 30 kg/m2
• drug allergy