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In the present study, the effect of a bolus of intrinsically labeled milk directly after one-legged NMES will be studied.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Protein ingestion | Placebo Comparator | Protein ingestion directly after the contralateral leg received NMES |
|
| Protein ingestion after NMES | Experimental | Ingestion of intrinsically labeled protein, directly after one hour of Neuromuscular electrical stimulation (NMES) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Enraf Nonius Tensmed S84 for Neuromuscular electrical stimulation (NMES) | Device | One our of one-legged neuromuscular electrical stimulation (NMES) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Tracer enrichment in the muscle biopsy | 4 hours after protein ingestion |
| Measure | Description | Time Frame |
|---|---|---|
| Fractional synthetic rate (FSR) | 0-4 hours after protein ingestion |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Luc JC van Loon, PhD | Maastricht UMC | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maastricht University Medical Centre | Maastricht | Netherlands |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32069356 | Derived | Gorissen SHM, Trommelen J, Kouw IWK, Holwerda AM, Pennings B, Groen BBL, Wall BT, Churchward-Venne TA, Horstman AMH, Koopman R, Burd NA, Fuchs CJ, Dirks ML, Res PT, Senden JMG, Steijns JMJM, de Groot LCPGM, Verdijk LB, van Loon LJC. Protein Type, Protein Dose, and Age Modulate Dietary Protein Digestion and Phenylalanine Absorption Kinetics and Plasma Phenylalanine Availability in Humans. J Nutr. 2020 Aug 1;150(8):2041-2050. doi: 10.1093/jn/nxaa024. |
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| No Enraf Nonius Tensmed S84 for Neuromuscular electrical stimulation (NMES) NMES | Device | No neuromuscular electrical stimulation (NMES) will be applied in the control leg |
|
| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
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