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This study aims to investigate the effects of supplementation of protein plus sessions of electrostimulation on muscle mass, length of hospital stay, readmission and mortality of hospitalized elderly.
Hospitalized elderly people show malnutrition, physical inactivity, and pronounced systemic inflammation which may be exacerbated the catabolic state and promote drastic muscle wasting during the hospitalization and, thus increasing the length of stay, morbidity, and mortality. Therefore, the aim of this study is to investigate the effects of supplementation of protein plus sessions of electrostimulation on muscle mass, length of hospital stay, readmission, and mortality of hospitalized elderly.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention | Experimental | Patients allocated to this arm will be submitted to intervention (protein supplementation plus neuromuscular electrostimulation). |
|
| Placebo | Placebo Comparator | Patients allocated to this arm will be submitted to a placebo intervention (isocaloric supplement plus sham for neuromuscular electrostimulation). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Protein supplementation | Dietary Supplement | Patients will receive diary 2 doses of the protein supplement |
|
| Measure | Description | Time Frame |
|---|---|---|
| Vastus Lateralis Muscle Cross-sectional Area | Vastus Lateralis Muscle Cross-sectional Area will be assessed through ultrasound | From date of admission until the date of medical discharge. Up to 30 days. |
| Measure | Description | Time Frame |
|---|---|---|
| Muscle function | Muscle function evaluated trough battery of test | From date of admission until the date of medical discharge. Up to 30 days. |
| Nutritional status | Nutritional status will be assessed through nutritional records during hospital stay |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hamilton Roschel, PhD | Contact | +551130618789 | hars@usp.br |
| Name | Affiliation | Role |
|---|---|---|
| Hamilton Roschel, PhD | University of Sao Paulo General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Sao Paulo | Recruiting | São Paulo | 05508-030 | Brazil |
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| Neuromuscular electrostimulation. | Device | Patients will receive diary sessions of neuromuscular electrostimulation. |
|
| Placebo (isocaloric supplement) | Dietary Supplement | Patients will receive diary 2 doses of the isocaloric supplement |
|
| Sham for neuromuscular electrostimulation. | Device | Patients will not receive neuromuscular electrostimulation. |
|
| From date of admission until the date of medical discharge. Up to 30 days. |
| Handgrip strength | Strength will be evaluated using handgrip strength test | From date of admission until the date of medical discharge. Up to 30 days. |
| Functional independence | Functional independence will be assessed using Barthel Index | From date of admission until the date of medical discharge. Up to 30 days. |
| Length of hospital stay | Length of hospital stay will be the time (in days) until medical discharge. | From date of admission until the date of medical discharge. Up to 30 days. |
| Mortality | Mortality rate in percent | From date of admission until the date of medical discharge. Up to 30 days. |
| Hospital readmission post-medical discharge | Hospital readmission post-medical discharge will be the number of times that he is admitted in the hospital post-medical discharge. | 6 months post-medical discharge |
| Health costs | Health costs will be estimated by means of the questionnaire with questions about the use of health services or equipment. | 6 months post-medical discharge |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| ID | Term |
|---|---|
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
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