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The effect of administration of vitamin D is tested on the long-term control of blood sugar (as measured by HbA1-c levels in blood) and mean blood pressure (as measured by 24 hour blood pressure profiles)in patients with stable type 2 diabetes mellitus
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| vitamin D | Active Comparator | Intervention: Intramuscular injection of 300 000 U of 25(OH)vitamin D |
|
| placebo | Placebo Comparator | administration of 0.9 % NaCl as a placebo |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 25(OH) vitamin D | Drug | 300 000 U intramuscularly, one dosage, in subjects with 25 (OH) vit D levels below 80 nmol/L, another dosage of 150 000 U after 3 months if 25(OH)vit D levels continue to be below 80 nmol/L. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in HBA1-c levels | 3 and 6 months | |
| 24 hour mean blood pressure | 3 and 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| plasma glucose | 3 and 6 months | |
| HOMA | 6 months |
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Inclusion criteria
Exclusion criteria
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| Name | Affiliation | Role |
|---|---|---|
| Reto Krapf, MD | Department of Medicine, Kantonsspital Bruderholz, University of Basel, Switzerland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of medicine, Kantonsspital Bruderholz | Bruderholz/Basel | Basel-Landschaft | CH-4101 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24652692 | Derived | Jehle S, Lardi A, Felix B, Hulter HN, Stettler C, Krapf R. Effect of large doses of parenteral vitamin D on glycaemic control and calcium/phosphate metabolism in patients with stable type 2 diabetes mellitus: a randomised, placebo-controlled, prospective pilot study. Swiss Med Wkly. 2014 Mar 20;144:w13942. doi: 10.4414/smw.2014.13942. |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D014807 | Vitamin D |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D012632 | Secosteroids |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
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| 0.9 % NaCl | Drug | 1 ml of 0.9 % of NaCl at the beginning and 0.5 ml of 0.9 % NaCl after three months |
|
| D004700 | Endocrine System Diseases |
| D002712 |
| Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |