Effect of Vitamin D Supplementation on Hemoglobin A1c in Patients With Uncontrolled Type 2 Diabetes Mellitus

Effect of Vitamin D Supplementation on Hemoglobin A1c in Patients With Uncontrolled Type 2 Diabetes Mellitus

The purpose of this study is to determine if daily supplementation with 2000 International Units of Vitamin D will improve hemoglobin A1c in uncontrolled type 2 diabetics.

Vitamin D is typically understood to support musculoskeletal health when administered concomitantly with calcium. A number of recent studies suggest, however, that this important nutrient may play a significant role in many pathophysiological processes, including diabetes mellitus. With the prevalence of diabetes mellitus ever increasing, novel mechanisms for controlling blood glucose and hemoglobin A1c are being sought to help prevent the costly and debilitating complications of this chronic disease.

Inclusion Criteria:

• Type 2 diabetes mellitus
• Hemoglobin A1c >7% measured in the 3 months prior to randomization
• Age 21 to 75 years

Exclusion Criteria:

• Renal insufficiency (defined as CrCl <30mL/min)
• Gestational diabetes
• Malabsorption syndrome
• Patients taking vitamin D supplements at doses >400 international units daily