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Consumption of whole grains has been heavily endorsed by both government and major health agencies, as evidenced in Health Canada's Food Guide, the US Department of Agriculture's Food Pyramid, and the Heart and Stroke Foundation's healthy eating guide. Whole grains have been championed for their proposed cardioprotective and weight control effects as suggested by epidemiological studies. The health benefits of whole grain products may be attributable to their nutrient composition, which contains dietary fibre, protein and several essential nutrients. There has also been a concurrent increase in seed consumption. Seeds have a similar and potentially superior nutritional composition to whole grains and they are rich in mammalian lignans and polyunsaturated fats, especially the highly valued omega-3 fatty acids. Preliminary studies on seeds have shown that they impart health benefits similar to those imparted by whole grains. Consumer choices regarding seed consumption may be based on their potential health benefits. Furthermore, they may also be affected by subjective sensory factors, such as appearance, taste and pre-conceived perceptions. Therefore, this study will compare the health properties of four seeds and their effects on appetite and sensory parameters in healthy individuals. These four seeds will be that of flax, poppy and sesame, due to their popularity and consumption as well as Salba, which has also recently received much attention for its associated health benefits.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Salba | Experimental | 25g of ground Salba baked into a bran muffin |
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| Poppy | Experimental | 25g of ground poppy seeds baked into a bran muffin |
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| Flaxseed | Experimental | 25g of ground flaxseed baked into a bran muffin |
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| Sesame | Experimental | 25g of ground sesame seeds baked into a bran muffin |
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| Wheat Bran | Placebo Comparator | Bran muffin matched for total available carbohydrates, total dietary fibre and calories |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Salba | Dietary Supplement | 25g of ground Salba baked into a bran muffin matched for total available carbohydrate (50g), total dietary fibre (15g), and calories (494.5 kcal) with the addition of flour, inulin or canola oil. One of five muffins (Salba, Poppy, Sesame, Flax, Bran) will be administered at each visit. |
| Measure | Description | Time Frame |
|---|---|---|
| Postprandial Blood Glucose | At each visit, postprandial blood glucose will be measured every 15 minutes over 3 hours. | 3 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Blood Pressure | At each visit, brachial blood pressure will be measured every 30 minutes over 3 hours. | 3 hours |
| Arterial Stiffness | At each visit, arterial stiffness (assessed by central augmentation index) will be measured every 30 minutes over 3 hours. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Vladimir Vuksan, PhD | Unity Health Toronto | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| St. Michael's Hospital | Toronto | Ontario | L3R 5G4 | Canada |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| C483301 | S-adenosyl-L-methionine (R,S)-reticuline 7-O-methyltransferase |
| D008043 | Linseed Oil |
| D004043 | Dietary Fiber |
| ID | Term |
|---|---|
| D005224 | Fats, Unsaturated |
| D005223 | Fats |
| D008055 | Lipids |
| D010938 | Plant Oils |
| D009821 |
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|
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| Poppy | Dietary Supplement | 25g of ground Poppy Seeds baked into a bran muffin matched for total available carbohydrate (50g), total dietary fibre (15g), and calories (494.5 kcal) with the addition of flour, inulin or canola oil. One of five muffins (Salba, Poppy, Sesame, Flax, Bran) will be administered at each visit. |
|
|
| Flaxseed | Dietary Supplement | 25g of ground Flaxseed baked into a bran muffin matched for total available carbohydrate (50g), total dietary fibre (15g), and calories (494.5 kcal) with the addition of flour, inulin or canola oil. One of five muffins (Salba, Poppy, Sesame, Flax, Bran) will be administered at each visit. |
|
|
| Sesame | Dietary Supplement | 25g of ground Sesame Seeds baked into a bran muffin matched for total available carbohydrate (50g), total dietary fibre (15g), and calories (494.5 kcal) with the addition of flour, inulin or canola oil. One of five muffins (Salba, Poppy, Sesame, Flax, Bran) will be administered at each visit. |
|
|
| Wheat Bran | Dietary Supplement | Bran muffin matched for total available carbohydrate (50g), total dietary fibre (15g), and calories (494.5 kcal). One of five muffins (Salba, Poppy, Sesame, Flax, Bran) will be administered at each visit. |
|
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| 3 hours |
| Palatability | At each visit, participants will record their subjective ratings using a 100mm visual analogue scale and these ratings will be combined into a total subjective palatability score. | 3 hours |
| Personal Preference | At each visit, participants will record their subjective ratings using a 100mm visual analogue scale and these ratings will be combined into a total subjective personal preference score. | 3 hours |
| Satiety | At each visit, participants will record their subjective ratings using a 100mm visual analogue scale and these ratings will be combined into a total subjective appetite score. | 3 hours |
| Oils |
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
| D004040 | Dietary Carbohydrates |
| D002241 | Carbohydrates |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |