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| Name | Class |
|---|---|
| ZonMw: The Netherlands Organisation for Health Research and Development | OTHER |
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Almost half of the Dutch population is currently characterized by overweight and obesity. Losing weight is not the problem in obesity treatment, it is the seemingly obligatory weight regain after weight loss: the yoyo-effect. The primary objective of this study is to investigate the association between the weight-loss-induced cellular stress response and the rate of weight regain. The secondary objective is to investigate the differences in cellular stress response and weight regain after rapid and slow weight loss. To investigate this, subjects will receive meal replacements replacing either all or part of the daily meals during the intervention period. THe first group will consume 500 kcal/d diet for 5 weeks while the second group consumes a 1250 kcal/d diet for 3 months, both followed by 1 week normalization and a 2 week strict weight maintenance diet. During the 9-month follow-up period subjects will receive dietary advice according to the Dutch recommendations for healthy eating. The association between the amount of weight regain after the weight loss period and changes in adipokines, parameters of adipocyte metabolism, in vivo adipose tissue metabolism, adipocyte extracellular matrix gene expression profiles, adipocyte stress protein expression and gene polymorphisms in selected genes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Very Low Calorie Diet | Experimental |
| |
| Low Calorie Diet | Active Comparator | 1250 kcal diet in which Modifast is given in combination with a normal diet |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Meal replacement diet using Modifast | Other | modifast intensive diet replacing all regular meals (500 kcal/d) for 5 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| change in weight following weight loss | VLCD diet group | at 9 weeks and at 46 weeks |
| change in weight following weight loss | LCD diet group | at 16 weeks and at 53 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| change in adipokine profile due to dietary intervention (VLCD-group) | In VLCD-group. Parameters of adipokine profile, including: leptin, acylation stimulating protein (ASP/C3adesarg), adiponectin, resistin, IL-6, RBP4, PAI-1, ACE, FGF-21, Vaspin, Apelin, Nesfatin-1 and TNFa | at baseline and after 5 weeks of VLCD diet |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Marleen van Baak, Professor | Maastricht University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maastricht University | Maastricht | Limburg | 6200 MD | Netherlands |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35366329 | Derived | Qiao Q, Bouwman FG, van Baak MA, Roumans NJT, Vink RG, Mariman ECM. Plasma Levels of Triglycerides and IL-6 Are Associated With Weight Regain and Fat Mass Expansion. J Clin Endocrinol Metab. 2022 Jun 16;107(7):1920-1929. doi: 10.1210/clinem/dgac198. | |
| 32015415 | Derived | Tareen SHK, Kutmon M, de Kok TM, Mariman ECM, van Baak MA, Evelo CT, Adriaens ME, Arts ICW. Stratifying cellular metabolism during weight loss: an interplay of metabolism, metabolic flexibility and inflammation. Sci Rep. 2020 Feb 3;10(1):1651. doi: 10.1038/s41598-020-58358-z. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D015431 | Weight Loss |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| Normal diet combined with Modifast diet | Other | Combination of modifast and regular diet (1250 kcal/d) for 3 months |
|
| change in adipokine during weight stable-period (VLCD-group) |
In VLCD-group. Parameters of adipokine profile, including: leptin, acylation stimulating protein (ASP/C3adesarg), adiponectin, resistin, IL-6, RBP4, PAI-1, ACE, FGF-21, Vaspin, Apelin, Nesfatin-1 and TNFa |
| after 5 weeks of VLCD diet and after 9 weeks |
| change in adipokine profile during follow-up (VLCD-group) | In VLCD-group. Parameters of adipokine profile, including: leptin, acylation stimulating protein (ASP/C3adesarg), adiponectin, resistin, IL-6, RBP4, PAI-1, ACE, FGF-21, Vaspin, Apelin, Nesfatin-1 and TNFa | at 9 weeks and after follow-up at 46 weeks |
| change in adipokine profile due to dietary intervention (LCD-group) | In LCD-group. Parameters of adipokine profile, including: leptin, acylation stimulating protein (ASP/C3adesarg), adiponectin, resistin, IL-6, RBP4, PAI-1, ACE, FGF-21, Vaspin, Apelin, Nesfatin-1 and TNFa | at baseline and after 12 weeks of LCD diet |
| change in adipokine profile during weight-stable period (LCD-group) | In LCD-group. Parameters of adipokine profile, including: leptin, acylation stimulating protein (ASP/C3adesarg), adiponectin, resistin, IL-6, RBP4, PAI-1, ACE, FGF-21, Vaspin, Apelin, Nesfatin-1 and TNFa | after 12 weeks of LCD diet and at 16 weeks |
| change in adipokine profile during follow-up (LCD-group) | In LCD-group. Parameters of adipokine profile, including: leptin, acylation stimulating protein (ASP/C3adesarg), adiponectin, resistin, IL-6, RBP4, PAI-1, ACE, FGF-21, Vaspin, Apelin, Nesfatin-1 and TNFa | at 16 weeks and after follow-up at 53 weeks |
| Changes in adipokine profile in the LCD-group compared to the VLCD-group | In LCD-group. Parameters of adipokine profile, including: leptin, acylation stimulating protein (ASP/C3adesarg), adiponectin, resistin, IL-6, RBP4, PAI-1, ACE, FGF-21, Vaspin, Apelin, Nesfatin-1 and TNFa | at baseline, at 5, 9, 12, 16, 46 and 53 weeks |
| change in adipokine profile in relation to weight regain during follow-up | In LCD-group and VLCD-group Parameters of adipokine profile, including: leptin, acylation stimulating protein (ASP/C3adesarg), adiponectin, resistin, IL-6, RBP4, PAI-1, ACE, FGF-21, Vaspin, Apelin, Nesfatin-1 and TNFa | at baseline, at 5, 9, 12, 16, 46 and 53 weeks |
| change in parameters of adipocyte fat metabolism due to dietary intervention (VLCD-group) | In VLCD-group. Parameters of adipocyte fat metabolism:
| at baseline and after 5 weeks of VLCD diet |
| change in parameters of adipocyte fat metabolism during weight-stable period (VLCD-group) | In VLCD-group. Parameters of adipocyte fat metabolism:
| after 5 weeks of VLCD diet and at 9 weeks |
| change in parameters of adipocyte fat metabolism during follow-up period (VLCD-group) | In VLCD-group. Parameters of adipocyte fat metabolism:
| at 9 weeks and after follow-up at 46 weeks |
| change in parameters of adipocyte fat metabolism due to dietary intervention (LCD-group) | In LCD-group. Parameters of adipocyte fat metabolism:
| at baseline and after 12 weeks of LCD diet |
| change in parameters of adipocyte fat metabolism during weight-stable period (LCD-group) | In LCD-group. Parameters of adipocyte fat metabolism:
| after 12 weeks of LCD diet and at 16 weeks |
| change in parameters of adipocyte fat metabolism during follow-up (LCD-group) | In LCD-group. Parameters of adipocyte fat metabolism:
| at 16 weeks and after follow-up at 53 weeks |
| Changes in parameters of adipocyte fat metabolism in the LCD-group compared to the VLCD-group | Parameters of adipocyte fat metabolism:
| at baseline, at 5, 9, 12, 16, 46 and 53 weeks |
| change in parameters of adipocyte fat metabolism in relation to weight regain during follow-up | In LCD-group and VLCD-group. Parameters of adipocyte fat metabolism:
| at baseline, at 5, 9, 12, 16, 46 and 53 weeks |
| change in in-vivo adipose tissue metabolism due to dietary intervention (VLCD-group) | In VLCD-group. In-vivo adipose tissue metabolism assessed in fasting and postprandial conditions:
| at baseline and after 5 weeks of VLCD diet |
| change in in-vivo adipose tissue metabolism during weight-stable period (VLCD-group) | In VLCD-group. In-vivo adipose tissue metabolism assessed in fasting and postprandial conditions:
| after 5 weeks of VLCD diet and at 9 weeks |
| change in in-vivo adipose tissue metabolism during follow-up period (VLCD-group) | In VLCD-group. In-vivo adipose tissue metabolism assessed in fasting and postprandial conditions:
| at 9 weeks and after follow-up period at 46 weeks |
| change in in-vivo adipose tissue metabolism due to dietary intervention (LCD-group) | In LCD-group. In-vivo adipose tissue metabolism assessed in fasting and postprandial conditions:
| at baseline and after 12 weeks of LCD diet |
| change in in-vivo adipose tissue metabolism during weight-stable period (LCD-group) | In LCD-group. In-vivo adipose tissue metabolism assessed in fasting and postprandial conditions:
| after 12 weeks of LCD diet and at 16 weeks |
| change in in-vivo adipose tissue metabolism during follow-up period (LCD-group) | In LCD-group. In-vivo adipose tissue metabolism assessed in fasting and postprandial conditions:
| at 16 weeks and after follow-up period at 53 weeks |
| change in in-vivo adipose tissue metabolism in the LCD-group compared to the VLCD-group | In-vivo adipose tissue metabolism assessed in fasting and postprandial conditions:
| at baseline, at 5, 9, 12, 16, 46 and 53 weeks |
| change in in-vivo adipose tissue metabolism in relation to weight regain during follow-up | In LCD-group and VLCD-group In-vivo adipose tissue metabolism assessed in fasting and postprandial conditions:
| at baseline, at 5, 9, 12, 16, 46 and 53 weeks |
| change in the adipocyte extracellular matrix gene and protein expression profile due to dietary intervention (VLCD-group) | VLCD diet group Adipocyte extracellular matrix gene expression profile assessed:
| at baseline and after 5 weeks of VLCD diet |
| change in the adipocyte extracellular matrix gene and protein expression profile during weight-stable period (VLCD-group) | VLCD diet group Adipocyte extracellular matrix gene expression profile assessed:
| after 5 weeks of VLCD diet and at 9 weeks |
| change in the adipocyte extracellular matrix gene and protein expression profile during follow-up period (VLCD-group) | VLCD diet group Adipocyte extracellular matrix gene expression profile assessed:
| at 9 weeks and after follow-up period at 46 weeks |
| change in the adipocyte extracellular matrix gene and protein expression profile due to dietary intervention (LCD-group) | LCD diet group Adipocyte extracellular matrix gene expression profile assessed:
| at baseline and after 12 weeks of LCD diet |
| change in the adipocyte extracellular matrix gene and protein expression profile during weight-stable period (LCD-group) | LCD diet group Adipocyte extracellular matrix gene expression profile assessed:
| after 12 weeks of LCD diet and at 16 weeks |
| change in the adipocyte extracellular matrix gene and protein expression profile during follow-up period (LCD-group) | LCD diet group Adipocyte extracellular matrix gene expression profile assessed:
| at 16 weeks and after follow-up period |
| change in the adipocyte extracellular matrix gene and protein expression profile in the LCD-group compared to the VLCD-group | Adipocyte extracellular matrix gene expression profile assessed:
| at baseline, at 5, 9, 12, 16, 46 and 53 weeks |
| change in the adipocyte extracellular matrix gene and protein expression profile in relation to weight regain during follow-up | In LCD-group and VLCD-group Adipocyte extracellular matrix gene expression profile assessed:
| at baseline, at 5, 9, 12, 16, 46 and 53 weeks |
| change in adipocyte stress proteins expression due to dietary intervention (VLCD-group) | VLCD diet group Adipocyte stress proteins expression:
| at baseline and after 5 weeks of VLCD diet |
| change in adipocyte stress proteins expression during weight-stable period (VLCD-group) | VLCD diet group Adipocyte stress proteins expression:
| after 5 weeks of VLCD diet and at 9 weeks |
| change in adipocyte stress proteins expression during follow-up period (VLCD-group) | VLCD diet group Adipocyte stress proteins expression:
| at 9 weeks and after follow-up period at week 46 |
| change in adipocyte stress proteins expression due to dietary intervention (LCD-group) | LCD diet group Adipocyte stress proteins expression:
| at baseline and after 12 weeks of LCD diet |
| change in adipocyte stress proteins expression during weight-stable period (LCD-group) | LCD diet group Adipocyte stress proteins expression:
| after 12 weeks of LCD diet and at week 16 |
| change in adipocyte stress proteins expression during follow-up period (LCD-group) | LCD diet group Adipocyte stress proteins expression:
| at week 16 and after follow-up period at 53 weeks |
| change in adipocyte stress proteins expression in the LCD-group compared to the VLCD-group | Adipocyte stress proteins expression:
| at baseline, at 5, 9, 12, 16, 46 and 53 weeks |
| change in adipocyte stress proteins expression in relation to weight regain during follow-up | In LCD-group and VLCD-group Adipocyte stress proteins expression:
| at baseline, at 5, 9, 12, 16, 46 and 53 weeks |
| change in physiological parameters due to dietary intervention (VLCD-group) | Physiological parameters: Blood pressure, waist-, and hip-circumference, weight, BMI, age, body fat | at baseline and after 5 weeks of VLCD diet |
| change in physiological parameters during weight-stable period (VLCD-group) | Physiological parameters: Blood pressure, waist-, and hip-circumference, weight, BMI, age, body fat | after 5 weeks of VLCD diet and at 9 weeks |
| change in physiological parameters during follow-up period (VLCD-group) | Physiological parameters: Blood pressure, waist-, and hip-circumference, weight, BMI, age, body fat | at 9 weeks and after follow-up at 46 weeks |
| change in physiological parameters due to dietary intervention (LCD-group) | Physiological parameters: Blood pressure, waist-, and hip-circumference, weight, BMI, age, body fat | at baseline and after 12 weeks of LCD diet |
| change in physiological parameters during weight-stable period (LCD-group) | Physiological parameters: Blood pressure, waist-, and hip-circumference, weight, BMI, age, body fat | after 12 weeks of LCD diet and at 16 weeks |
| change in physiological parameters during follow-up (LCD-group) | Physiological parameters: Blood pressure, waist-, and hip-circumference, weight, BMI, age, body fat | at 16 weeks and after follow-up at 53 weeks |
| Changes in physiological parameters in the LCD-group compared to the VLCD-group | Physiological parameters: Blood pressure, waist-, and hip-circumference, weight, BMI, age, body fat | at baseline, at 5, 9, 12, 16, 46 and 53 weeks |
| Changes in physiological parameters in relation to weight regain during follow-up | Physiological parameters: Blood pressure, waist-, and hip-circumference, weight, BMI, age, body fat | at baseline, at 5, 9, 12, 16, 46 and 53 weeks |
| change in plasma metabolic parameters due to dietary intervention (VLCD-group) | Plasma metabolic parameters are measured in fasting and postprandial conditions, focused on: Glucose, insulin, free fatty acid, glycerol and triglycerides | at baseline and after 5 weeks of VLCD diet |
| change in plasma metabolic parameters during weight-stable period (VLCD-group) | Plasma metabolic parameters are measured in fasting and postprandial conditions, focused on: Glucose, insulin, free fatty acid, glycerol and triglycerides | after 5 weeks of VLCD diet and at 9 weeks |
| change in plasma metabolic parameters during follow-up period (VLCD-group) | Plasma metabolic parameters are measured in fasting and postprandial conditions, focused on: Glucose, insulin, free fatty acid, glycerol and triglycerides | at 9 weeks and after follow-up at 46 weeks |
| change in plasma metabolic parameters due to dietary intervention (LCD-group) | Plasma metabolic parameters are measured in fasting and postprandial conditions, focused on: Glucose, insulin, free fatty acid, glycerol and triglycerides | at baseline and after 12 weeks of LCD diet |
| change in plasma metabolic parameters during weight-stable period (LCD-group) | Plasma metabolic parameters are measured in fasting and postprandial conditions, focused on: Glucose, insulin, free fatty acid, glycerol and triglycerides | after 12 weeks of LCD diet and at 16 weeks |
| change in plasma metabolic parameters during follow-up (LCD-group) | Plasma metabolic parameters are measured in fasting and postprandial conditions, focused on: Glucose, insulin, free fatty acid, glycerol and triglycerides | at 16 weeks and after follow-up at 53 weeks |
| Changes in plasma metabolic parameters in the LCD-group compared to the VLCD-group | Plasma metabolic parameters are measured in fasting and postprandial conditions, focused on: Glucose, insulin, free fatty acid, glycerol and triglycerides | at baseline, at 5, 9, 12, 16, 46 and 53 weeks |
| Changes in plasma metabolic parameters in relation to weight regain during follow-up | In LCD-group and VLCD-group Plasma metabolic parameters are measured in fasting and postprandial conditions, focused on: Glucose, insulin, free fatty acid, glycerol and triglycerides | at baseline, at 5, 9, 12, 16, 46 and 53 weeks |
| change in fat cell size and fat cell number due to the dietary intervention (VLCD-group) | at baseline and after 5 weeks of VLCD diet |
| change in fat cell size and fat cell number during weight-stable period (VLCD-group) | after 5 weeks of VLCD diet and at 9 weeks |
| change in fat cell size and fat cell number during follow-up period (VLCD-group) | at 9 weeks and after follow-up at 46 weeks |
| change in fat cell size and fat cell number due to dietary intervention (LCD-group) | at baseline and after 12 weeks of LCD diet |
| change in fat cell size and fat cell number during weight-stable period (LCD-group) | after 12 weeks of LCD diet and at 16 weeks |
| change in fat cell size and fat cell number during follow-up (LCD-group) | at 16 weeks and after follow-up at 53 weeks |
| Changes in fat cell size and fat cell number in the LCD-group compared to the VLCD-group | at baseline, at 5, 9, 12, 16, 46 and 53 weeks |
| Changes in fat cell size and fat cell number in relation to weight regain after weight loss | In LCD-group and VLCD-group | at baseline, at 5, 9, 12, 16, 46 and 53 weeks |
| change in breath volatile organic compounds due to the dietary intervention (VLCD-group) | at baseline and after 5 weeks of VLCD diet |
| change in breath volatile organic compounds during weight-stable period (VLCD-group) | after 5 weeks of VLCD diet and at 9 weeks |
| change in breath volatile organic compounds during follow-up period (VLCD-group) | at 9 weeks and after follow-up at 46 weeks |
| change in breath volatile organic compounds due to dietary intervention (LCD-group) | at baseline and after 12 weeks of LCD diet |
| change in breath volatile organic compounds during weight-stable period (LCD-group) | after 12 weeks of LCD diet and at 16 weeks |
| change in breath volatile organic compounds during follow-up (LCD-group) | at 16 weeks and after follow-up at 53 weeks |
| Changes in breath volatile organic compounds in the LCD-group compared to the VLCD-group | at baseline, at 5, 9, 12, 16, 46 and 53 weeks |
| Changes in breath volatile organic compounds in relation to weight regain during follow-up | In LCD-group and VLCD-group | at baseline, at 5, 9, 12, 16, 46 and 53 weeks |
| change in inflammatory parameters due to the dietary intervention (VLCD-group) | In VLCD-group. Inflammatory parameters are analyzed in:
| at baseline and after 5 weeks of VLCD diet |
| change in inflammatory parameters during weight-stable period (VLCD-group) | In VLCD-group. Inflammatory parameters are analyzed in:
| after 5 weeks of VLCD diet and at 9 weeks |
| change in inflammatory parameters during follow-up period (VLCD-group) | In VLCD-group. Inflammatory parameters are analyzed in:
| at 9 weeks and after follow-up at 46 weeks |
| change in inflammatory parameters due to dietary intervention (LCD-group) | In LCD-group. Inflammatory parameters are analyzed in:
| at baseline and after 12 weeks of LCD diet |
| change in inflammatory parameters during weight-stable period (LCD-group) | In LCD-group. Inflammatory parameters are analyzed in:
| after 12 weeks of LCD diet and at 16 weeks |
| change in inflammatory parameters during follow-up (LCD-group) | In LCD-group. Inflammatory parameters are analyzed in:
| at 16 weeks and after follow-up at 53 weeks |
| Changes in inflammatory parameters in the LCD-group compared to the VLCD-group | Inflammatory parameters are analyzed in:
| at baseline, at 5, 9, 12, 16, 46 and 53 weeks |
| Changes in inflammatory parameters in relation to weight regain during the follow-up | Inflammatory parameters are analyzed in:
| at baseline, at 5, 9, 12, 16, 46 and 53 weeks |
| Changes in protein concentration of metabolic parameters due to the dietary intervention (VLCD-group) | Protein concentrations of metabolic parameters, including: CD36, FABP4, Vimentin, Vimentin25, HSL, ALDOC, ALDOA, TUBB5, ANXA2, HADH, ACAA2 and ACADS | at baseline and after 5 weeks of VLCD diet |
| Changes in protein concentration of metabolic parameters during weight-stable period (VLCD-group) | Protein concentrations of metabolic parameters, including: CD36, FABP4, Vimentin, Vimentin25, HSL, ALDOC, ALDOA, TUBB5, ANXA2, HADH, ACAA2 and ACADS | after 5 weeks of VLCD diet and at 9 weeks |
| change in protein concentration of metabolic parameters during follow-up (VLCD-group) | Protein concentrations of metabolic parameters, including: CD36, FABP4, Vimentin, Vimentin25, HSL, ALDOC, ALDOA, TUBB5, ANXA2, HADH, ACAA2 and ACADS | at 9 weeks and after follow-up at 46 weeks |
| change in protein concentration of metabolic parameters due to dietary intervention (LCD-group) | Protein concentrations of metabolic parameters, including: CD36, FABP4, Vimentin, Vimentin25, HSL, ALDOC, ALDOA, TUBB5, ANXA2, HADH, ACAA2 and ACADS | at baseline and after 12 weeks of LCD diet |
| change in protein concentration of metabolic parameters during weight-stable period (LCD-group) | Protein concentrations of metabolic parameters, including: CD36, FABP4, Vimentin, Vimentin25, HSL, ALDOC, ALDOA, TUBB5, ANXA2, HADH, ACAA2 and ACADS | after 12 weeks of LCD diet and at 16 weeks |
| change in protein concentration of metabolic parameters during follow-up (LCD-group) | Protein concentrations of metabolic parameters, including: CD36, FABP4, Vimentin, Vimentin25, HSL, ALDOC, ALDOA, TUBB5, ANXA2, HADH, ACAA2 and ACADS | at 16 weeks and after follow-up at 53 weeks |
| change in protein concentration of metabolic parameters in the LCD-group compared to the VLCD-group | Protein concentrations of metabolic parameters, including: CD36, FABP4, Vimentin, Vimentin25, HSL, ALDOC, ALDOA, TUBB5, ANXA2, HADH, ACAA2 and ACADS | at baseline, at 5, 9, 12, 16, 46 and 53 weeks |
| change in protein concentration of metabolic parameters in relation to weight regain during follow-up | In LCD-group and VLCD-group Protein concentrations of metabolic parameters, including: CD36, FABP4, Vimentin, Vimentin25, HSL, ALDOC, ALDOA, TUBB5, ANXA2, HADH, ACAA2 and ACADS | at baseline, at 5, 9, 12, 16, 46 and 53 weeks |
| 29399976 | Derived | Roumans NJT, Wang P, Vink RG, van Baak MA, Mariman ECM. Combined Analysis of Stress- and ECM-Related Genes in Their Effect on Weight Regain. Obesity (Silver Spring). 2018 Mar;26(3):492-498. doi: 10.1002/oby.22093. Epub 2018 Feb 5. |
| 28639346 | Derived | Vink RG, Roumans NJ, van der Kolk BW, Fazelzadeh P, Boekschoten MV, Mariman EC, van Baak MA. Adipose Tissue Meal-Derived Fatty Acid Uptake Before and After Diet-Induced Weight Loss in Adults with Overweight and Obesity. Obesity (Silver Spring). 2017 Aug;25(8):1391-1399. doi: 10.1002/oby.21903. Epub 2017 Jun 22. |
| 28298393 | Derived | Roumans NJ, Vink RG, Fazelzadeh P, van Baak MA, Mariman EC. A role for leukocyte integrins and extracellular matrix remodeling of adipose tissue in the risk of weight regain after weight loss. Am J Clin Nutr. 2017 May;105(5):1054-1062. doi: 10.3945/ajcn.116.148874. Epub 2017 Mar 15. |
| 28179648 | Derived | Vink RG, Roumans NJ, Cajlakovic M, Cleutjens JPM, Boekschoten MV, Fazelzadeh P, Vogel MAA, Blaak EE, Mariman EC, van Baak MA, Goossens GH. Diet-induced weight loss decreases adipose tissue oxygen tension with parallel changes in adipose tissue phenotype and insulin sensitivity in overweight humans. Int J Obes (Lond). 2017 May;41(5):722-728. doi: 10.1038/ijo.2017.38. Epub 2017 Feb 9. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001836 | Body Weight Changes |