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The purpose of this study is to examine the effect of diet-induced weight loss on the levels of circulating nutrients and hormones which are involved in feelings of hunger and satiety.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Optifast VLCD | Dietary Supplement | Meal replacement, three times daily for 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Difference in fasting and/or post-prandial hormone levels following weight loss and after weight maintenance compared with baseline | 2, 6 and 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Difference in fasting and/or post-prandial hormone levels in ketotic compared with non-ketotic state | week 8 vs week 10 | |
| Correlation of fasting and post-prandial hormone levels with ratings of hunger and satiety | 0, 2, 6 and 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Heidelberg Repatriation Hospital | Melbourne | Victoria | 3081 | Australia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22029981 | Derived | Sumithran P, Prendergast LA, Delbridge E, Purcell K, Shulkes A, Kriketos A, Proietto J. Long-term persistence of hormonal adaptations to weight loss. N Engl J Med. 2011 Oct 27;365(17):1597-604. doi: 10.1056/NEJMoa1105816. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D015431 | Weight Loss |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| Association of psychosocial factors with successful weight maintenance | 12 months |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001836 | Body Weight Changes |