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| ID | Type | Description | Link |
|---|---|---|---|
| COG-ANBL12B6 | Other Identifier | Children's Oncology Group | |
| CDR0000728527 | Other Identifier | Clinical Trials.gov | |
| ANBL12B6 | Other Identifier | Children's Oncology Group | |
| NCI-2012-00706 | Registry Identifier | CTRP (Clinical Trial Reporting Program) |
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
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RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer.
PURPOSE: This research trial studies gene expression in samples from younger patients with neuroblastoma.
OBJECTIVES:
OUTLINE: Archived paraffin-embedded tissue and plasma samples are analyzed for TβRIII expression, TGF-β signaling, and SMAD3 expression and phosphorylation by immunohistochemistry, enzyme-linked immunosorbent assay (ELISA), and other assays. Surface expression of TβRIII in the neuroblastic and stromal tumor components are correlated with matched circulating levels of soluble TβRIII. Results are then correlated with each patient's outcome data, including stage.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| gene expression analysis | Genetic | |||
| protein expression analysis | Genetic | |||
| enzyme-linked immunosorbent assay | Other | |||
| immunohistochemistry staining method | Other | |||
| laboratory biomarker analysis | Other | |||
| medical chart review | Other |
| Measure | Description | Time Frame |
|---|---|---|
| Expression of TβRIII in the neuroblastic tumor and stroma of patients with advanced-stage NBL | ||
| Correlation between TβRIII levels and TGF-β signaling correlate with NBL stage, tumor stroma content, surface TβRIII expression, and TGF-β signaling |
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DISEASE CHARACTERISTICS:
Tissue samples and matched plasma samples available from 1 of the following groups:
Clinical and/or outcome data associated with the tissue and plasma samples including INSS stage, age, MYCN amplification status, chromosomal alterations, and 5-year survival, if known
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
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Patients with low-stage (International Neuroblastoma Staging System [INSS] stage 1 or 2) neuroblastoma (NBL), patients with advanced-stage (INSS stage 3 or 4) NBL, or patients with stage 4S NBL
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| Name | Affiliation | Role |
|---|---|---|
| Gerard C. Blobe, MD, PhD | Duke University | Principal Investigator |
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
| D009447 | Neuroblastoma |
| ID | Term |
|---|---|
| D018241 | Neuroectodermal Tumors, Primitive, Peripheral |
| D018242 | Neuroectodermal Tumors, Primitive |
| D018302 | Neoplasms, Neuroepithelial |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009380 | Neoplasms, Nerve Tissue |
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| ID | Term |
|---|---|
| D020869 | Gene Expression Profiling |
| D004797 | Enzyme-Linked Immunosorbent Assay |
| D007150 | Immunohistochemistry |
| ID | Term |
|---|---|
| D005821 | Genetic Techniques |
| D008919 | Investigative Techniques |
| D007124 | Immunoenzyme Techniques |
| D007118 | Immunoassay |
| D007158 | Immunologic Techniques |
| D007163 | Immunosorbent Techniques |
| D015336 | Molecular Probe Techniques |
| D006651 | Histocytochemistry |
| D003584 | Cytological Techniques |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D006652 | Histological Techniques |
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