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| ID | Type | Description | Link |
|---|---|---|---|
| COG-ANBL12B4 | Other Identifier | Children's Oncology Group | |
| NCI-2012-00091 | Registry Identifier | CTRP (Clinical Trial Reporting Program) | |
| ANBL12B4 | Other Identifier | Children's Oncology Group |
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
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RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research trial studies biomarkers in tumor samples from younger patients with neuroblastoma.
OBJECTIVES:
OUTLINE: Banked tumor tissue samples are analyzed for expression of UBE4B, hrs, members of the ubiquitination protein complex, growth factor receptors, and 1p36 deletion status by immunohistochemistry (IHC), fluorescent microscopy, and fluorescence in situ hybridization (FISH).
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| fluorescence in situ hybridization | Genetic | |||
| gene expression analysis | Genetic | |||
| microarray analysis | Genetic | |||
| mutation analysis | Genetic | |||
| protein analysis | Genetic | |||
| immunohistochemistry staining method | Other | |||
| laboratory biomarker analysis | Other |
| Measure | Description | Time Frame |
|---|---|---|
| Expression of UBE4B, hrs, and members of the ubiquitination protein complex | ||
| Expression levels and cellular localization of the UBE4B, hrs, and growth factor receptors | ||
| 1p36 deletion status and its association with UBE4B |
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DISEASE CHARACTERISTICS:
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
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Patients With Neuroblastoma
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| Name | Affiliation | Role |
|---|---|---|
| Peter Zage, MD, PhD | Texas Children's Cancer Center | Principal Investigator |
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Tumor samples
| microscopy | Other |
| ID | Term |
|---|---|
| D009447 | Neuroblastoma |
| ID | Term |
|---|---|
| D018241 | Neuroectodermal Tumors, Primitive, Peripheral |
| D018242 | Neuroectodermal Tumors, Primitive |
| D018302 | Neoplasms, Neuroepithelial |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009380 | Neoplasms, Nerve Tissue |
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| ID | Term |
|---|---|
| D017404 | In Situ Hybridization, Fluorescence |
| D020869 | Gene Expression Profiling |
| D046228 | Microarray Analysis |
| D007150 | Immunohistochemistry |
| D008853 | Microscopy |
| ID | Term |
|---|---|
| D017403 | In Situ Hybridization |
| D013194 | Staining and Labeling |
| D016591 | Histocytological Preparation Techniques |
| D003584 | Cytological Techniques |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D006652 | Histological Techniques |
| D008919 | Investigative Techniques |
| D020732 | Cytogenetic Analysis |
| D005821 | Genetic Techniques |
| D009693 | Nucleic Acid Hybridization |
| D046208 | Microchip Analytical Procedures |
| D006651 | Histocytochemistry |
| D007158 | Immunologic Techniques |
| D003952 | Diagnostic Imaging |
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