Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| University of Copenhagen | OTHER |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The aim of this study is to investigate the role of transmission of vagal cholinerg for the GLP-1 potentiation of the glucose stimulated insulin secretion and the cephalic insulin response by using atropin administration.
The hypothesis is that a great deal of the effects of GLP-1 is mediated via the nervous system and for this reason the investigators will research individuals with an intact nervous supply with and without atropin administration.
GLP-1 is a importent enterogastron and incretin hormone. Rapid degradation of GLP-1 by dipeptidyl peptidase 4 (DPP-4) suggests that GLP-1 may act locally (through vagal afferents) before being degraded. We aimed to clarify the role of vagal innervation on the incretin effect.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Atropin | Active Comparator | Atropin |
|
| Placebo | Placebo Comparator | Saline |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Atropine | Drug | 1 mg as a bolus and the and infusion of 80 ng/kg/min for either 105 or 145 minuts. |
|
| Measure | Description | Time Frame |
|---|---|---|
| insulin secretion | The insulin secretion during lightly elevated blood glucose during GLP-1 infusions with and without atropin administration is evaluated. Also the insulin secretion during lightly elevated blood glucose during a sham-feeding with and without atropin administration is evaluated. | tree hours |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma PP | 20 blood samlpes will be drawn during lightly elevated blood glucose during a sham-feeding with and without atropin administration. | 20 time points within tree hours |
| Plasma glucose |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Astrid Plamboeck, MD | Contact | + 45 26208174 | astridp@sund.ku.dk |
| Name | Affiliation | Role |
|---|---|---|
| Tina Vilsbøll, MD, Dr. med | Diabetes research Division, Department of Internal Medicine, Gentofte Hospital, Copenhagen, Denamrk | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Diabetes research Division, Department of Internal Medicin, Gentofte Hospital | Recruiting | Hellerup | 2900 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26492921 | Derived | Veedfald S, Plamboeck A, Deacon CF, Hartmann B, Knop FK, Vilsboll T, Holst JJ. Cephalic phase secretion of insulin and other enteropancreatic hormones in humans. Am J Physiol Gastrointest Liver Physiol. 2016 Jan 1;310(1):G43-51. doi: 10.1152/ajpgi.00222.2015. Epub 2015 Oct 22. | |
| 26136531 | Derived | Plamboeck A, Veedfald S, Deacon CF, Hartmann B, Vilsboll T, Knop FK, Holst JJ. The role of efferent cholinergic transmission for the insulinotropic and glucagonostatic effects of GLP-1. Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R544-51. doi: 10.1152/ajpregu.00123.2015. Epub 2015 Jul 1. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Placebo | Drug |
|
30 blood samlpes will be drawn during lightly elevated blood glucose during a sham-feeding with and without atropin administration.
| 30 within tree hours |
| Plasma GLP-1 | 20 blood samlpes will be drawn during lightly elevated blood glucose during a sham-feeding with and without atropin administration. | 20 time points within tree hours |
| Plasma GLP-1 | 18 blood samples will be drawn during lightly elevated blood glucose during GLP-1 infusions with and without atropin administration. | 18 time points within tree hours |
| Plasma GLP-2 | 18 blood samples will be drawn during lightly elevated blood glucose during GLP-1 infusions with and without atropin administration. | 18 time points within tree hours |
| Plasma GIP | 18 blood samples will be drawn during lightly elevated blood glucose during GLP-1 infusions with and without atropin administration. | 18 timepoints within tree hours |
| Plasma glucagon | 18 blood samples will be drawn during lightly elevated blood glucose during GLP-1 infusions with and without atropin administration. | 18 timepoints within tree hours |
| Plasma glucose | 33 blood samples will be drawn during lightly elevated blood glucose during GLP-1 infusions with and without atropin administration. | 33 timepoints within tree hours |
| Diabetes Research Division, Department of Internal Medicine, Gentofte Hospital, Copenhagen Denmark | Recruiting | Hellerup | 2900 | Denmark |
|
| ID | Term |
|---|---|
| D001285 | Atropine |
| ID | Term |
|---|---|
| D001286 | Atropine Derivatives |
| D014326 | Tropanes |
| D053961 | Azabicyclo Compounds |
| D001372 | Aza Compounds |
| D009930 | Organic Chemicals |
| D001533 | Belladonna Alkaloids |
| D012991 | Solanaceous Alkaloids |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D019086 | Bridged Bicyclo Compounds, Heterocyclic |
| D006572 | Heterocyclic Compounds, Bridged-Ring |
Not provided
Not provided