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| Name | Class |
|---|---|
| Rigshospitalet, Denmark | OTHER |
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Investigation of the importance of vagal signaling for the glucohomeostatic effects of GLP-1. The study will include physiological studies of truncally vagotomized participants and matched controls.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Enteral fructose with DPP-4 inhibition | Experimental | Enteral fructose + DPP-4 inhibition (sitagliptin) After DPP4 inhibition using Tablet Sitagliptin 100mg on the evening before and on the morning of experimentation enteral fructose is given via an intestinal tube (intrajejunal) to either truncally vagotomised and control individuals. |
|
| Enteral fructose without DPP-4 inhibition | Experimental | Enteral fructose without DPP-4 inhibition (sitagliptin) After DPP4 inhibition using Tablet Sitagliptin 100mg on the evening before and on the morning of experimentation enteral fructose is given via an intestinal tube (intrajejunal) to either truncally vagotomised and control individuals. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tablet Sitagliptin 100mg (evening before and morning of experiments) | Drug | On one of two experiment days participants will have Dipeptidyl peptidase 4 activity inhibited using a DPP-4 inhibitor (Sitagliptin). |
| Measure | Description | Time Frame |
|---|---|---|
| Insulin secretion | Evaluated by c-peptide and insulin levels - Plasma collected up to 4 hours will be analyzed for peptide hormones | up to 4 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Glucagon secretion | Plasma collected over 4 hours will be analyzed for peptide hormones | 4 hours |
| Glucose levels | Plasma collected over 4 hours will be analyzed for glucose |
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Truncally vagotomized individuals:
Inclusion Criteria:
Exclusion Criteria:
Matched controls:
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Surgery C, Rigshospitalet | Recruiting | Copenhagen | 2100 | Denmark |
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| Intestinal Fructose administration | Other | On both experimental days fructose (35g dissolved in water, total volume 100mL) will be administered via an intrajejunal tube |
|
| 4 hours |
| Pancreatic Polypeptide levels | Plasma collected over 4 hours will be analyzed for peptide hormones | 4 hours |
| GIP secretion | Plasma collected over 4 hours will be analyzed for peptide hormones | 4 hours |