GLP-1 Signaling in Truncally Vagotomized Subjects

Vagal Mechanisms Mediating the Effects of Glucagon-Like Peptide 1 (GLP-1) on the Endocrine Pancreas - the Entero-endocrine Axis.

Investigation of the importance of vagal signaling for the glucohomeostatic effects of GLP-1. The study will include physiological studies of truncally vagotomized participants and matched controls.

Truncally vagotomized individuals:

Inclusion Criteria:

• Normal fasting plasma glucose
• Normal haemoglobin concentration
• Cardiaresection with a pyloroplasty
• Informed consent

Exclusion Criteria:

• Diabetes mellitus
• Disposition for diabetes mellitus
• Intestinal disease (apart from cardia resection+pyloroplasty)
• Disposition of inflammatory bowel disease
• Intestinal resection (apart from cardia resection+pyloroplasty)
• Body mass index (BMI) > 27,5 kg/m2
• Tobacco use
• Nephropathy (se-creatinine> 130 µM and/or albuminuria)
• Liver disease (ALAT and/or ASAT >2 × refference value)
• known heart condition
• medicinal use, that may not be paused for 12 hours
• Obstipation
• swallowing difficulties
• previous problems with intestinal tube placement
• Latex allergy
• Fructose malabsorption
• Known diseases in the pharynx
• Previous facial or cranial fractures
• Sinusitis
• Bleeding diathesis

Matched controls:

Inclusion Criteria:

• Normal fasting plasma glucose
• Normal haemoglobin concentration
• Informed consent

Exclusion Criteria:

• Cardiaresection with a pyloroplasty
• Diabetes mellitus
• Disposition for diabetes mellitus
• Intestinal disease (apart from cardia resection+pyloroplasty)
• Disposition of inflammatory bowel disease
• Intestinal resection tarmresektion (apart from cardia resection+pyloroplasty)
• Body mass index (BMI) > 27,5 kg/m2
• Tobacco use
• Nephropathy (se-creatinine> 130 µM and/or albuminuria)
• Liver disease (ALAT and/or ASAT >2 × refference value)
• known heart condition
• medicinal use, that may not be paused for 12 hours
• Obstipation
• swallowing difficulties
• previous problems with intestinal tube placement
• Latex allergy
• Fructose malabsorption
• Known diseases in the pharynx
• Previous facial or cranial fractures
• Sinusitis
• Bleeding diathesis