Pharmacological Intervention in Insulin Resistance Targeting Autonomic Nerve Activity

Pharmacological Intervention in Insulin Resistance Targeting Autonomic Nerve Activity - a Concept Study in Mani

The present study on pharmacological intervention in autonomic nervous dysregulation(parasympathetic dysfunction,) regarding insulin resistance, is a concept testing in humans tohelp identify potential new pharmacological target sites in the central nervous system.

Inclusion Criteria:

• Signed written informed consent
• BMI of lean and abdominally obese men and women
• weight stable

Exclusion Criteria:

• Ongoing clinically significant diseases
• History of repeated syncope
• resting pulse<50 or systolic blood pressure <100