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With the epidemic of obesity and diabetes growing around the world, Kochujang (KCJ) may be potentially effective in preventing and treating obesity and cardiovascular risks if proven in humans. However, human trial still have not been reported with KCJ supplementation. In the present study, we investigated the hypothesis that KCJ supplementation can be decrease the body fat and improve blood lipid profiles in overweight adults.
The aim of this study was to evaluate the efficacy of KCJ supplementation on anthropometric parameters, visceral fat/subcutaneous fat, and blood lipid profiles in overweight subjects.
Sixty overweight subjects with BMI >25 kg/m2 and waist-hip-ratio (WHR) ≥ 0.90 for men and ≥ 0.85 for women were randomly assigned to either KCJ supplement (n=30, 32 g/day) or placebo (n=30, 32 g/day) group for 12 weeks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Kochujang(32g) | Experimental |
| |
| placebo(32g) | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Kochujang | Dietary Supplement | Kochujang (32g/day) for 12weeks. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Visceral fat | after 12 weeks of consumption |
| Measure | Description | Time Frame |
|---|---|---|
| Body Mass Index | after 12 weeks of consumption | |
| Subcutaneous fat | after 12weeks | |
| Triglyceride |
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Inclusion Criteria:
Exclusion Criteria:
lipid metabolic disorders
>10% changes in body weight in the past 3 months
Cardiovascular disease such as arrhythmia, heart failure, myocardial infarction, and wearing pacemaker
Allergy or hypersensitivity to any of the ingredients in the test products - History of reaction to any of the experimental products or of gastrointestinal diseases such as Crohn's disease or gastrointestinal surgery
Participation in other clinical trials within the past 2 months
Abnormal hepatic liver function, renal disease such as acute
Use of anti-psychosis drug therapy within 2 months
Laboratory test, medical or psychological conditions deemed by the investigators to interfere with successful participation in the study
History of alcohol or substance abuse
Pregnancy or breastfeeding
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| Name | Affiliation | Role |
|---|---|---|
| Soo-Wan Chae, Ph.D, MD | Chonbuk National University Hospital | Study Chair |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23442518 | Derived | Cha YS, Kim SR, Yang JA, Back HI, Kim MG, Jung SJ, Song WO, Chae SW. Kochujang, fermented soybean-based red pepper paste, decreases visceral fat and improves blood lipid profiles in overweight adults. Nutr Metab (Lond). 2013 Feb 26;10(1):24. doi: 10.1186/1743-7075-10-24. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Feb 23, 2012 | |
| Unrelease | Yes | |
| Release | Mar 1, 2012 | |
| Reset | Apr 4, 2012 | |
| Release | Oct 24, 2012 | |
| Unrelease | Yes | |
| Release | Dec 17, 2019 | |
| Reset | Jan 3, 2020 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Feb 23, 2012 | Yes | |||
| Mar 1, 2012 |
| ID | Term |
|---|---|
| D050177 | Overweight |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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| placebo |
| Dietary Supplement |
placebo(32g/day) for 12weeks |
|
| after 12week of consumption |
| Atherosclerosis index | after 12weeks of consumption |
| Apolipoprotein | after 12weeks of consumption |
| Apr 4, 2012 |
| Oct 24, 2012 | Yes |
| Dec 17, 2019 | Jan 3, 2020 |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |