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| Name | Class |
|---|---|
| Unilever R&D | INDUSTRY |
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Cardiovascular disease (CVD) is the greatest cause of morbidity and mortality in the UK. Abnormalities in the concentration and/or composition of lipoproteins (the lipid carrying particles), in particular low density lipoproteins (LDL) in circulation, is one of the most important physiological defects contributing to the development of CVD.
The LDL cholesterol (LDLC) response to fatty acid change is in part mediated by the APOE genotype, with E4 individuals (25% of the UK population) being most responsive to changes in dietary fats, showing greater reductions when low levels of saturated fats or fish oils are consumed and greater increases when high levels of these fats are consumed. Therefore the aims of the present study is to understand the mechanism that regulates the higher LDLC response associated with saturated fatty acids and fish oil consumption in healthy men prospectively recruited based on their APOE genotype.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High saturated fat meal | Experimental |
| |
| Saturated fatty acid and fish oils meal | Experimental | Equivalent to two portions of oily fish |
|
| High unsaturated fat meal | Active Comparator | Provided a fatty acid profile representative of a typical UK diet |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High saturated fat meal | Dietary Supplement | Volunteers consumed a single test meal breakfast containing 53 g of fat, of which 50 g was substituted for saturated fats. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Impact of APOE genotype and dietary fat composition in plasma lipids | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Cardiovascular disease risk factors | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Julie A Lovegrove, Professor | University of Reading | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Food and Nutritional Sciences, University of Reading | Reading | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28276521 | Derived | Calabuig-Navarro MV, Jackson KG, Kemp CF, Leake DS, Walden CM, Lovegrove JA, Minihane AM. A randomized trial and novel SPR technique identifies altered lipoprotein-LDL receptor binding as a mechanism underlying elevated LDL-cholesterol in APOE4s. Sci Rep. 2017 Mar 9;7:44119. doi: 10.1038/srep44119. | |
| 25332476 | Derived |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D005227 | Fatty Acids |
| ID | Term |
|---|---|
| D008055 | Lipids |
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| Saturated fatty acids and fish oil meal | Dietary Supplement | Volunteers consumed a single test meal breakfast containing 53 g of fat, of which 50 g was substituted for saturated fats and fish oil. The dose of fish oils was equivalent to two portions of oily fish. |
|
| High unsaturated fat meal | Dietary Supplement | Volunteers consumed a single test meal breakfast containing 53 g of fat, of which 50 g was substituted for unsaturated fats. It provided a fatty acid profile representative of a typical UK diet. |
|
| Calabuig-Navarro MV, Jackson KG, Walden CM, Minihane AM, Lovegrove JA. Apolipoprotein E genotype has a modest impact on the postprandial plasma response to meals of varying fat composition in healthy men in a randomized controlled trial. J Nutr. 2014 Nov;144(11):1775-80. doi: 10.3945/jn.114.197244. Epub 2014 Sep 17. |