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MicroRNAs (miRNAs) are a novel class of short RNAs which have shown to be dysregulated in a variety of cancers. Data of miRNA expression in cutaneous squamous cell carcinoma (cSCC) is very limited and microarray based genome wide miRNA expression profiles of cSCC have not been investigated so far.
Patients with cutaneous SCC were enrolled in the present study. Tumor biopsies were taken from the center of the tumor. Adjacent healthy skin was biopsied as a control (intraindividual control). miRNA expression profiles of specimen were detected by microarray miRNA expression profiling. Microarray results were confirmed by TaqMan real-time quantitative polymerase chain reaction (RT-PCR).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| squamous cell carcinoma | |||
| non-lesional skin |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with cutaneous squamous cell carcinoma
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| Name | Affiliation | Role |
|---|---|---|
| Falk G Bechara, PD Dr. | Department of Dermatology, Venereology and Allergology, Dermatologic Surgery Unit, Ruhr-University Bochum | Study Director |
| Peter Altmeyer, Prof. Dr. | Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum | Study Chair |
| Michael Sand, Dr. | Department of Dermatology, Venereology and Allergology, Dermatologic Surgery Unit, Ruhr-University Bochum | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Dermatology, Venereology and Allergology, Dermatologic Surgery Unit, Ruhr-University Bochum | Bochum | North Rhine-Westphalia | 44791 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23026055 | Result | Sand M, Skrygan M, Georgas D, Sand D, Hahn SA, Gambichler T, Altmeyer P, Bechara FG. Microarray analysis of microRNA expression in cutaneous squamous cell carcinoma. J Dermatol Sci. 2012 Dec;68(3):119-26. doi: 10.1016/j.jdermsci.2012.09.004. Epub 2012 Sep 13. |
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cutaneous squamous cell carcinoma (SCC) non.lesional skin