The purpose of this study is to determine whether continuous infusion of palonosetron after its prophylactic single injection can further reduce the incidence of postoperative nausea and vomiting in patients undergoing gynecological laparoscopic surgery.

Inclusion Criteria:

• ASA Physical Status 1 or 2
• Elective gynaecological laparoscopic surgery of ≥ 1h duration

Exclusion Criteria:

• Anti-emetics, steroids, or psychoactive medications within 24 h of study initiation
• Vomiting or retching in the 24 h preceding surgery
• Cancer chemotherapy within 4 weeks or emetogenic radiotherapy within 8 weeks before study entry
• Ongoing vomiting from gastrointestinal disease