Comparison of TIVA (Total Intravenous Anesthesia) and TIVA Plus Palonosetron in Preventing Postoperative Nausea and Vomiting

Comparative Study of TIVA(Total Intravenous Anesthesia) and TIVA Plus Palonosetron in Preventing PONV(Postoperative Nausea and Vomiting)

A total intravenous anesthesia (TIVA) is a useful anesthetic technique that reduces the incidence of postoperative nausea and vomiting (PONV).

Investigator hypothesized the incidence of PONV can be further reduced when palonosetron is added to TIVA.

Inclusion Criteria:

• ASA Physical Status 1 or 2
• Elective gynaecological laparoscopic surgery of ≥ 1h duration

Exclusion Criteria:

• Anti-emetics, steroids, or psychoactive medications within 24 h of study initiation
• Vomiting or retching in the 24 h preceding surgery
• Cancer chemotherapy within 4 weeks or emetogenic radiotherapy within 8 weeks before study entry
• Ongoing vomiting from gastrointestinal disease