Comparison of Palonosetron Versus Combination of Palonosetron and Dexamethasone for Preventing Postoperative Vomiting in Patients Receiving Fentanyl by Patient-controlled Analgesia After Minor Orthopedic Surgery

Postoperative nausea and vomiting (PONV) is related with extended hospital day and risk factor of aspiration pneumonia. Postoperative patient controlled intravenous analgesia is related with postoperative nausea and vomiting. Selective 5-HT3 antagonist, Palonosetron, is the most recent medication for prevention of PONV. Purpose of our study is comparison of PONV preventive effect of palonosetron and combination of palonosetron and dexamethasone.

Inclusion Criteria:

• patients who are undergoing minor orthopedic surgery.
• IV patient controlled analgesia

Exclusion Criteria:

• 1. minority (0~19 year)
• patients who are belongs to ASA class 3 or more, and have underlying complicated cardiovascular or psychological disease.
• Steroid medication
• Diabetes Mellitus medication