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| Name | Class |
|---|---|
| Universitetssenteret på Kjeller | OTHER |
| Center for Healthy Aging | UNKNOWN |
| The Novo Nordic Foundation | OTHER |
| Copenhagen University Hospital, Denmark |
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The aim of the study is to 1) delineate the molecular mechanisms behind the large variation in insulin sensitivity among apparently healthy subjects and to 2) establish the dose-response relationship between physical training and a) metabolic health, b) appetite and c) cultural health.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 600 kcal/day | Experimental | Exercise combusting 600 kcal/day, 7 days/week for 12 weeks. |
|
| 300 kcal/day | Experimental | Exercise combusting 300 kcal/day, 7 days/week for 12 weeks. |
|
| Sedentary | No Intervention | Continued sedentary living. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise | Behavioral | Daily exercise for 12 weeks. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in insulin sensitivity at 12 weeks | As measured by a hyperinsulinemic, isoglycemic clamp combined with skeletal muscle and adipose tissue biopsies as well as low-dose PET/CT. | At baseline and 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in body composition af 2, 6 and 12 weeks | As measured by DEXA- and MRI-scanning. | At baseline, 2, 6 and 12 weeks |
| Change from baseline in appetite at 12 weeks | As measured by food records, controlled diets, meal tests and appetite hormones |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Biomedical Sciences, The University of Copenhagen | Copenhagen | DK-2200 | Denmark |
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| Label | URL |
|---|---|
| Click here for more information about this study: Physical Activity for a Long and Healthy Life | View source |
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| ID | Term |
|---|---|
| D050177 | Overweight |
| D007333 | Insulin Resistance |
| D003924 | Diabetes Mellitus, Type 2 |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| OTHER |
| Glostrup University Hospital, Copenhagen | OTHER |
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| At baseline and 12 weeks |
| Motivational factors for exercise | Ethnographic field work | During and for up to 1½ year after the intervention |
| Diameter of t-tubuli in skeletal muscle | As measured in skeletal muscle biopsies by electron and confocal microscopy | At baseline |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D003920 | Diabetes Mellitus |
| D004700 | Endocrine System Diseases |
| D001519 | Behavior |