Physical Activity for a Long and Healthy Life

Physical Activity for a Long and Healthy Life - Project FINE

The aim of the study is to 1) delineate the molecular mechanisms behind the large variation in insulin sensitivity among apparently healthy subjects and to 2) establish the dose-response relationship between physical training and a) metabolic health, b) appetite and c) cultural health.

Inclusion Criteria:

• Healthy according to interview
• Caucasian
• Sedentary, Vo2max < 45 ml/kg/min
• BMI 25-30 kg/m2
• Fat percentage 25% <
• Weight stable (+/- 2 kg within past 6 months)

Exclusion Criteria:

• First degree relatives with type 2 diabetes
• Hemoglobin concentration < 8 mmol/l
• Fasting plasma glucose 6.1 mmol/l <
• Blood pressure 140/90 mmHg <
• Regular intake of medicine