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| ID | Type | Description | Link |
|---|---|---|---|
| EA4/042/11 | Other Identifier | Ethics Committee Charité - Universitätsmedizin Berlin |
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| Name | Class |
|---|---|
| Center for Stroke Research Berlin | OTHER |
| Medical Institute BMW-Berlin Marathon, Berlin, Germany | UNKNOWN |
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This prospective observational study will investigate the frequency of new onset atrial fibrillation (AF) and of further cardiac arrhythmias as well as of (clinically silent) cerebral lesions in endurance runners before, during and after the BMW-Berlin Marathon 2011.
Up to 120 experienced marathon runners will participate in the "Berlin Beat of Running Study" and will wear a transportable electrocardiogram (ECG) recorder at least 24 hours before, during and 24 hours after the BMW-Berlin Marathon. All participants will undergo brain MRI examinations to detect cerebral lesions within days before and after the marathon race, respectively. Moreover, serial blood samples will be taken a few days before, immediately after as well as a few days after the BMW-Berlin Marathon.
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| Measure | Description | Time Frame |
|---|---|---|
| Rate of cardiac arrhythmias in marathon runners detected by mobile ECG-recording | During ECG recording | Up to 48 hours after the marathon race. |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of (clinically silent) cerebral lesions detected by 3 Tesla brain MRI. | Up to 3 days after marathon. | 3 days |
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Inclusion Criteria:
Exclusion Criteria:
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Experienced marathon runners
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| Name | Affiliation | Role |
|---|---|---|
| Karl Georg Haeusler, MD | Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Germany. | Principal Investigator |
| Matthias Endres, MD | Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Germany | Study Chair |
| Wilhelm Haverkamp, MD | Departement of Cardiology, Campus Virchow, Charité - Universitätsmedizin Berlin, Germany | Study Chair |
| Matthias Kruell, MD | Medical Institute BMW-Berlin Marathon | Study Chair |
| Peter U Heuschmann, MD | Center for Stroke Research Berlin | Study Chair |
| Gerhard Jan Jungehuelsing, MD | Center for Stroke Research Berlin | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Center for Stroke Research Berlin | Berlin | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28775185 | Derived | Herm J, Topper A, Wutzler A, Kunze C, Krull M, Brechtel L, Lock J, Fiebach JB, Heuschmann PU, Haverkamp W, Endres M, Jungehulsing GJ, Haeusler KG. Frequency of exercise-induced ST-T-segment deviations and cardiac arrhythmias in recreational endurance athletes during a marathon race: results of the prospective observational Berlin Beat of Running study. BMJ Open. 2017 Aug 3;7(8):e015798. doi: 10.1136/bmjopen-2016-015798. | |
| 22938148 |
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| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D020521 | Stroke |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Whole blood samples
| Derived |
| Haeusler KG, Herm J, Kunze C, Krull M, Brechtel L, Lock J, Hohenhaus M, Heuschmann PU, Fiebach JB, Haverkamp W, Endres M, Jungehulsing GJ. Rate of cardiac arrhythmias and silent brain lesions in experienced marathon runners: rationale, design and baseline data of the Berlin Beat of Running study. BMC Cardiovasc Disord. 2012 Aug 31;12:69. doi: 10.1186/1471-2261-12-69. |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |