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Ten healthy subjects perform a baseline computer tomography (CT) of the heart and routine laboratory blood tests for myocardial injury and inflammation.
The same data are collected <24 hours after an endurance race corresponding to a maraton run (i.e. about 40 km of running and/or about 2.5 hours hard training or more). A third collection of lab tests and CT is done a couple of weeks after the race. Magnetic resonance imaging is also performed in parallell to the CT on occasions 2 and 3 in most subjects, serving as a reference for determination of myocardial blood flow.
Ten healthy subjects perform a baseline computer tomography (CT) of the heart and routine laboratory blood tests (troponin T, hs-CRP, CK-mb etc) for myocardial injury and inflammation.
The same data are collected <24 hours after an endurance race corresponding to a maraton run (i.e. about 40 km of running and/or about 2.5 hours hard training or more). A third collection of lab tests and CT is done a couple of weeks after the race. Magnetic resonance imaging (MRI) is also performed in parallell to the CT on occasions 2 and 3 in most subjects, serving as a reference for determination of myocardial blood flow. The CT of the heart includes contrast injection and blood flow will be determined by a recently developed based on very powerful computers using "machine learning".
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Endurance race | Experimental |
|
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Endurance Race | Behavioral | 1 CT and lab tests, 2 CT and lab tests within 24h of a race, 3 follow up investigations 1-2 weeks after the race with CT and lab tests |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in myocardial blood flow by the race? | Detection of potential differences in blood flow between occasion 1 and 2 and 3 | All investigations are performed < 2 months |
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Inclusion Criteria:
Healthy subjects, experienced in long distance running
Exclusion Criteria:
Significant renal, kidney, heart, liver or musculoskeletal disease.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fredrik H Nyström, MD PhD Professor | Contact | 0736569303 | +46 | fredrik.h.nystrom@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Linkoping | Recruiting | Linköping | 58185 | Sweden |
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