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| ID | Type | Description | Link |
|---|---|---|---|
| 40361/05 | Other Grant/Funding Number | Tekes, National Technology Agency of Finland |
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| Name | Class |
|---|---|
| VTT Technical Research Centre, Finland | OTHER |
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Dietary polyphenols might have beneficial effects on glucose and lipid metabolism based on the studies made in animals or cell cultures. The findings regarding the possible decrease of low-grade inflammation are existing also in humans. Low-grade inflammation has been suggested to be a mechanistic link between obesity and its consequences on cardiometabolic health. The aim of the present study is to examine the effect of diet rich in berries on glucose and lipid metabolism and inflammatory markers.
Berries are traditionally an important part of the Nordic diet. About 50 different berries are grown in the northern region, and about half of them are edible. Phenolic compounds are one of the most diverse group of secondary metabolites present in edible plants, and berries are especially rich in them. Flavonoids, phenolic acids, lignans and complex phenolic polymers (polymeric tannins) are typical for berries. Phenolic compounds are reported to have a variety of beneficial biological properties. They are potent antioxidants, and exhibit various other physiological activities including anti-inflammatory, antimicrobial, antiallergic, anticarcinogenic and antihypertensive activities. Epidemiological studies indicate that diet rich in phenolic compound correlates with lower risk of cancer and cardiovascular disease.
The aim of the present study is to examine the effect of diet rich in berries on glucose and lipid metabolism and inflammatory markers and gene expression profile in peripheral blood mononuclear cells (PBMCs) in subjects with features of metabolic syndrome.
Randomized, controlled clinical intervention including 4 wk run-in period, 8 wk dietary intervention and 4 wk recovery period was conducted.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SRC | Experimental | Strawberry, raspberry and cloudberry intervention for 8 weeks |
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| BB | Experimental | Bilberry intervention for 8 weeks |
|
| C | Experimental | Control diet with restricted berry consumption |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 300 g of strawberry, raspberry and cloudberry | Dietary Supplement | 100 g of strawberry puree, 100 g of frozen raspberries and 100 g frozen cloudberries were concumed daily for 8 weeks. Bilberry consumption was restricted. |
| Measure | Description | Time Frame |
|---|---|---|
| Glucose level | Fasting glucose level oral glucose tolerance status at study week 8 | week 8 |
| Cholesterol level | total, HDL and LDL cholesterol level at the study week 8 | week 8 |
| Inflammation markers | Various inflammation markers were measured at the study week 8 | week 8 |
| Measure | Description | Time Frame |
|---|---|---|
| Markers of sterol metabolism | Markers of cholesterol absorption and synthesis were measured | week 8 |
| gene expression in PBMCs | Global gene expression analyses in peripheral mononuclear cells (PBMC) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Riitta Törrönen, Adjunct Professor | University of Eastern Finland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Eastern Finland, Dpet of Public Health and Clinical Nutrition | Kuopio | FIN-70211 | Finland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23934737 | Derived | Puupponen-Pimia R, Seppanen-Laakso T, Kankainen M, Maukonen J, Torronen R, Kolehmainen M, Leppanen T, Moilanen E, Nohynek L, Aura AM, Poutanen K, Tomas-Barberan FA, Espin JC, Oksman-Caldentey KM. Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome. Mol Nutr Food Res. 2013 Dec;57(12):2258-63. doi: 10.1002/mnfr.201300280. Epub 2013 Aug 12. | |
| 22961907 |
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| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| D018149 | Glucose Intolerance |
| D050171 | Dyslipidemias |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| ID | Term |
|---|---|
| C073305 | Vaccinium myrtillus extract |
| D004032 | Diet |
| ID | Term |
|---|---|
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
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| 400 g of bilberry | Dietary Supplement | Equivalent amount to 400 g of fresh bilberries were consumed as 40 g of dried bilberries and as 200 g of frozen bilberries. Restriction of use of strawberries, raspberries and cloudberries were set. |
|
| Control diet | Other | Control diet, ie. habitual diet with restriction of berry consumption was consumed for eight weeks |
|
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| study week 8 |
| Derived |
| Kolehmainen M, Mykkanen O, Kirjavainen PV, Leppanen T, Moilanen E, Adriaens M, Laaksonen DE, Hallikainen M, Puupponen-Pimia R, Pulkkinen L, Mykkanen H, Gylling H, Poutanen K, Torronen R. Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome. Mol Nutr Food Res. 2012 Oct;56(10):1501-10. doi: 10.1002/mnfr.201200195. Epub 2012 Sep 7. |
| D009750 |
| Nutritional and Metabolic Diseases |
| D006943 | Hyperglycemia |
| D052439 | Lipid Metabolism Disorders |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |