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Cognitive and memory disorders are characterized of Alzheimer disease. In addition, psychologic and behavioural symptoms, called speak neuropsychiatric symptoms, are frequents and play an important role in prognostic and intervention. These symptoms are noticed before the diagnostic of dementia, their prevalence and their intensity increase with the evolution of disease. Apathy, which is characterized by a decrease of motivation, is the most frequent of this behaviour disrupt. Clinically, a decrease, or a totally, lack of interest, initiative and blunting emotional are noticed. Fundamentally, apathy is considered as a decrease of cognition and behaviour to "go in goal". Assessment of psychological and behavioural symptoms is realised principally with neuropsychiatric scales. These contribute to obtain particular informations about health of patient allowing by patient and caregiver discussions and impressions of clinician. These scales are simples but loss of subjectivity. An alternative of this method is the use of gerontechnology as actigraphy (system out-patient which records locomotive activity with the help of piezo-electrical sensor fixed on a bracelet) and video recording which is associated to an informatic treatment of signal in order event recognition.
The aim of study is to realise an objective assessment of activities "go in goal" during experimental sequence which has well-characterized acts, using at the same time an actigraphic record of activity "motive" (system of assessment indirect of apathy fit) and a video records which uses an informatic event recognition system. The assessment will realise with participants controls (n=30) and Alzheimer disease patients with (n=20) or without (n=20) apathy, during well-characterized records. The final aim is to obtain a particular assessment of some disorders behaviours, as apathy, which is principally characterize by a decrease of behaviours "to go in goal".
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| witness | Active Comparator | no mnesic complaint |
|
| Alzheimer disease with apathy | Experimental | Alzheimer's disease according to criteria of NINCDS-ADRDA with apathy |
|
| Alzheimer's disease without apathy | Experimental | Alzheimer's disease according to criteria of NINCDS-ADRDA without apathy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| observational | Other | Observation during a physical exercise |
|
| Measure | Description | Time Frame |
|---|---|---|
| stride and speed walking | one time point - at the only visit of protocol (day 1) |
| Measure | Description | Time Frame |
|---|---|---|
| For comparison between Alzheimer disease patients with (n=20) or without apathy, we use again stride and speed walking | one time point - at the only visit of protocol (day 1) | |
| For reproducibility, we use stride and speed walking | one time point - at the only visit of protocol (day 1) |
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Inclusion Criteria for no mnesic patient:
Inclusion Criteria for Alzheimer's patient:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Philippe ROBERT, PU-PH | Centre Hospitalier Universitaire de Nice | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital de Cimiez | Nice | 06000 | France |
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| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D057832 | Watchful Waiting |
| ID | Term |
|---|---|
| D017063 | Outcome Assessment, Health Care |
| D010043 | Outcome and Process Assessment, Health Care |
| D011787 | Quality of Health Care |
| D006298 | Health Services Administration |
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| Reliability is the sum of posture's concordance | one time point - at the only visit of protocol (day 1) |
| Relation between LF/HF variations and activity index | one time point - at the only visit of protocol (day 1) |
| D024801 |
| Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |