Comparative Assessment of the Clinical Utility of Ovarian Stimulation With Menotropin Versus Menotropin Plus GnRH Antagonist

Comparative Assessment of the Clinical Utility of Ovarian Stimulation With Menotropin Versus Menotropin Plus GnRH Antagonist Following Two Protocols of Ovulation Induction for Intrauterine Insemination

To assess the effectiveness of protocols of ovarian hyperstimulation combining urinary gonadotrophins + GnRH antagonist vs urinary gonadotrophins, to achieve clinical pregnancy in females undergoing intrauterine insemination.

Study hypothesis: protocols combining urinary gonadotrophins + GnRH antagonist should be more effective than monotherapy.

Inclusion Criteria:

• Women aged 18-36 years
• Body mass index (BMI) between 18 and 26
• Prolactin within the laboratory normal range
• Couples affected by sterility able to treat by IUI (intrauterine insemination)
• Patients undergoing Menopur® treatment
• Normal thyroid function
• Regular menses (21-35 days)
• Couples willing to participate in the study that have signed the informed consent form
• Seminal sample REM>3 million

Exclusion Criteria:

• Two previous ART (assisted reproductive technology) cycles without ongoing pregnancy
• Policystic ovarian syndrome
• Evidence of significant bacterial infection in the seminogram of the couple in the preceding 6 months