Assessment of the Effectiveness and Tolerability of Ovarian Hyperstimulation

Assessment of the Effectiveness and Tolerability of Ovarian Hyperstimulation Protocols Which Are the Most Common in Clinical Practice Using High Purified Gonadotrophins (u-FSH-HP y u-hMG-HP) in IVF/ICSI

The aim of the study is to assess the effectiveness of 5 mixed protocols of ovarian hyperstimulation with urinary gonadotrophins to achieve clinical pregnancy in females undergoing assisted reproductive techniques (IVF/ICSI) (in-vitro fertilisation/intracytoplasmic sperm injection).

Study hypothesis: mixed protocols with urinary FSH (follicle-stimulating hormone) and urinary hMG (human menopausal gonadotropin)should be more effective than monotherapy.

Inclusion Criteria:

• Body mass index (BMI) between 18 and 30
• Prolactin within the laboratory normal range
• Couples affected by sterility able to treat by IVF/ICSI (in-vitro fertilisation/intracytoplasmic sperm injection)
• Patients undergoing Menopur® and/or Bravelle® treatment
• Normal thyroid function
• Women not receiving clomifen citrate or gonadotrophins within one month prior study start
• Couples willing to participate in the study that have signed the informed consent form

Exclusion Criteria:

• Failure in 3 previous cycles of assisted reproduction IVF/ICSI (in-vitro fertilisation/intracytoplasmic sperm injection)
• Policystic ovarian syndrome
• Seminal samples not apt for IVF-ICSI (according to the criteria of each center)
• Evidence of significant bacterial infection in the seminogram of the couple in the preceding 6 months
• Antecedents of severe ovarian hyperstimulation syndrome (OHSS)
• Important systemic disease
• Pregnancy or contraindication to pregnancy